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Association of plasma manganese levels with chronic renal failure

Cristina Sánchez-González1, Carlos López-Chaves1, Jorge Gómez-Aracena2

  • 1Department of Physiology, Campus Cartuja, University of Granada, E-18071 Granada, Spain.

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
|May 26, 2015
PubMed

Insights

Chronic renal failure (CRF) patients show elevated plasma manganese (Mn) levels, which correlate with kidney dysfunction markers. This study investigated Mn levels in predialysis CRF patients and their relation to nutrient intake.

Area of Science:

  • Trace element metabolism
  • Nephrology
  • Clinical biochemistry

Background:

  • Manganese (Mn) is essential for bone formation and metabolism, but excess can be neurotoxic.
  • Limited data exist on manganese's role in chronic renal failure (CRF).
  • Understanding Mn levels in predialysis CRF is crucial for patient management.

Purpose of the Study:

  • To assess plasma manganese levels in predialysis CRF patients over 12 months.
  • To examine the relationship between plasma Mn and energy/macronutrient intake.
  • To correlate Mn levels with markers of renal function.

Main Methods:

  • A 12-month observational study involving 64 predialysis CRF patients and 62 healthy controls.
  • Measured plasma levels of creatinine, urea, uric acid, total protein, and manganese.
  • Calculated glomerular filtration rate (GFR) using the Cockcroft-Gault index.

Main Results:

  • CRF patients exhibited higher plasma creatinine, urea, uric acid, and manganese levels compared to controls.
  • A significantly lower GFR was observed in CRF patients.
  • Plasma Mn positively correlated with creatinine, urea, uric acid, and negatively with GFR and nutrient intake.

Conclusions:

  • Predialysis CRF is associated with increased circulating manganese levels.
  • Elevated plasma Mn in CRF patients may reflect impaired excretion or altered metabolism.
  • Further research is needed to elucidate the clinical implications of Mn dysregulation in CRF.
Keywords:
BMIChronic renal failureGenderManganese

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