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A fast heterogeneous algorithm for light fluence rate for prostate photodynamic therapy.

Chang Chang1, Ken K-H Wang1, Timothy C Zhu1

  • 1Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

Proceedings of Spie--The International Society for Optical Engineering
|May 26, 2015
PubMed
Summary

Accurate light fluence rate calculations in prostate photodynamic therapy (PDT) require accounting for optical heterogeneity. A new heterogeneous algorithm shows promise for optimizing PDT light delivery.

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Area of Science:

  • Biomedical Optics
  • Medical Physics
  • Photodynamic Therapy

Background:

  • Accurate light fluence rate distribution is crucial for effective prostate photodynamic therapy (PDT).
  • Optical heterogeneity in tissues significantly impacts light propagation.
  • Previous kernel-based methods offer accuracy comparable to Finite-element method (FEM).

Purpose of the Study:

  • To develop and implement a fast ray-tracing algorithm for calculating light fluence rate distribution in heterogeneous media.
  • To evaluate the accuracy of a new kernel-based method against FEM calculations and experimental measurements.
  • To assess the potential of the heterogeneous algorithm for optimizing interstitial PDT.

Main Methods:

  • Implementation of a fast ray-trace algorithm for kernel calculation.
Keywords:
Photodynamic therapylight dosimetrylight fluence

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  • Extension of the kernel method from point sources to linear sources by summation.
  • Comparison of kernel calculations with FEM simulations and in vivo light fluence rate measurements.

    • Main Results:

    • The implemented ray-trace algorithm significantly speeds up calculations.
    • Calculated fluence rates demonstrated similar distribution features compared to clinical measurements.
    • Peak fluence rate errors ranged from 30% to 70% when compared to measurements.

    Conclusions:

    • The developed heterogeneous algorithm is a potentially valuable tool for light fluence rate optimization in interstitial PDT.
    • The method accounts for optical heterogeneity, improving the accuracy of light dosimetry.
    • Further refinement may reduce discrepancies observed in peak fluence rate measurements.