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A robust platform for functional microgels via thiol-ene achemistry with reactive polyether-based nanoparticles.

Carolin Fleischmann1, Jeffrey Gopez2, Pontus Lundberg2

  • 1Institut für Organische Chemie und Makromolekulare Chemie, Heinrich Heine Universität Düsseldorf, Universitätstraße 1, D-40225 Düsseldorf, Germany ; Materials Research Laboratory, Department of Chemistry and Biochemistry, and the Materials Department, Santa Barbara, California 93106, USA.

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Summary

We developed crosslinked polyether particles for creating functional microgels. These versatile nanoparticles can be modified with various responsive groups and are degradable, offering broad applications in materials science.

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Nanotechnology

Background:

  • Developing versatile platforms for synthesizing functional microgels is crucial for advanced material applications.
  • Existing methods may lack control over particle properties or functionalization.
  • Bio-compatible materials are increasingly important for biomedical applications.

Purpose of the Study:

  • To develop a novel, reactive platform for preparing functional microgels.
  • To enable facile post-synthesis modification with diverse responsive groups.
  • To create degradable hydrogel particles with controlled properties.

Main Methods:

  • Utilized thiol-ene crosslinking of poly(allyl glycidyl ether) in miniemulsion droplets.
  • Employed a bio-compatible polyethylene glycol (PEG) block copolymer for particle stabilization.
  • Introduced reactive allyl units within the inner polymeric network and a PEG corona.
  • Performed subsequent thiol-ene functionalization for introducing responsive groups.
  • Incorporated cleavable ester groups into the crosslinker for degradability.

Main Results:

  • Successfully synthesized colloidal gels with a PEG corona and a reactive inner network.
  • Demonstrated the stability of allyl groups, allowing purification and storage.
  • Achieved facile introduction of various pH- and chemically-responsive groups.
  • Prepared microgel libraries with consistent size, surface functionality, and crosslinking density.
  • Confirmed degradability of hydrogel particles at elevated pH and under physiological esterase conditions.

Conclusions:

  • Developed a facile and versatile synthetic platform for functional microgels.
  • The platform allows for controlled introduction of responsive functionalities and tunable degradability.
  • These microgels offer significant potential for applications requiring tailored nanoparticle properties.