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Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability
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Improved Stability of Proline-Derived Direct Thrombin Inhibitors through Hydroxyl to Heterocycle Replacement

Harry R Chobanian1, Barbara Pio1, Yan Guo1

  • 1Departments of Medicinal Chemistry, Process Chemistry, Drug Metabolism and Pharmacokinetics, Preclinical Development, Pharmacology, and Thrombosis, Merck Research Laboratories , Kenilworth, New Jersey 07033, United States.

ACS Medicinal Chemistry Letters
|May 26, 2015
PubMed

Keywords:
Thrombindabigatranprolineserine proteasethrombosiswarfarin

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