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Bis-arylidene oxindole-betulinic Acid conjugate: a fluorescent cancer cell detector with potent anticancer activity
Abhishek Pal1, Anirban Ganguly2, Sumit Chowdhuri3
1Department of Chemistry, University of Calcutta , 92, A.P.C. Road, Kolkata 700 009, India ; Department of Organic Chemistry, Indian Association for Cultivation of Science , Jadavpur, Kolkata 700 032, India.
Abstract:
Molecules offering simultaneous detection and killing of cancer cells are advantageous. Hybrid of cancer cell-selective, ROS generator betulinic acid and bis-arylidene oxindole with amino propyl-linker is developed. With intrinsic fluorescence, the molecule exhibited cancer cell-specific residence. Further, it generated ROS, triggered apoptosis, and exhibited potent cytotoxicity in cancer cells selectively. We demonstrate the first example and use of isatins as betulinic acid conjugate for selective detection of cancer and subsequent killing of cancer cells via apoptosis.
