Comparison of one and two-day bowel preparation with polyethylene glycol in pediatric colonoscopy

Area of Science:

• Pediatric Gastroenterology
• Gastrointestinal Endoscopy
• Clinical Trial Methodology

Background:

• Effective colon preparation is crucial for pediatric colonoscopy but remains a challenge.
• Various regimens exist, yet optimal strategies for children are not definitively established.
• This study addresses the need for a well-tolerated and effective bowel preparation in pediatric patients.

Purpose of the Study:

• To evaluate the efficacy and safety of a one-day versus a two-day bowel preparation regimen in children undergoing colonoscopy.
• To compare successful colon cleansing rates between the two regimens.
• To assess patient compliance and adverse events associated with each preparation method.

Main Methods:

• A randomized clinical trial involving 100 pediatric patients (2-14 years) undergoing colonoscopy.
• Group one received a one-day regimen: polyethylene glycol (PEG) plus bisacodyl.
• Group two received a two-day regimen: PEG with fruit juices and bisacodyl.

Main Results:

• No significant differences in compliance, adverse effects, or complete colonoscopy rates between the one-day and two-day PEG plus bisacodyl groups.
• Excellent or good Boston scores were achieved in 70% (group one) and 72% (group two) of children.
• Similar rates of compliance and need for enemas were observed, with satisfactory preparation linked to higher compliance.

Conclusions:

• The one-day polyethylene glycol (PEG) plus bisacodyl regimen is a safe and effective alternative for pediatric bowel preparation.
• This regimen demonstrates comparable efficacy to the two-day approach with a favorable safety profile.
• The findings support the use of a simplified one-day preparation for pediatric colonoscopy.