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Two Methods for Decellularization of Plant Tissues for Tissue Engineering Applications

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Current controversies over bioresorbable scaffolds.

Z Raval¹, A Kirtane, J Moses

¹Columbia University Medical Center, New York Presbyterian Hospital, New York, NY, USA - zraval9@gmail.com.

Minerva Cardioangiologica

|May 27, 2015

Summary

Coronary intervention evolved from balloon angioplasty to bioresorbable scaffolds (BRS). Emerging data shows BRS promise, but controversies and concerns remain.

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Area of Science:

Cardiovascular Medicine
Interventional Cardiology
Biomaterials Science

Background:

The field of coronary intervention has advanced significantly since 1977.
Evidence-based improvements in technology and patient outcomes have been driven by extensive data generation.

Purpose of the Study:

To outline the evolution of coronary intervention from plain old balloon angioplasty (POBA) to bioresorbable scaffolds (BRS).
To discuss emerging data, promise, controversies, and residual concerns surrounding BRS technology.

Main Methods:

Review of historical advancements in coronary intervention.
Analysis of data from registries and randomized trials on BRS.
Discussion of current evidence and unresolved issues regarding BRS.

Main Results:

Coronary intervention has progressed from POBA to novel therapies like BRS.
Emerging data suggests potential benefits of BRS in certain patient populations.
Significant controversies and residual concerns regarding BRS safety and efficacy persist.

Conclusions:

Bioresorbable scaffolds represent a significant advancement in coronary intervention.
Further research and long-term data are needed to fully address BRS controversies and concerns.
The future of coronary intervention includes evaluating and refining novel therapies like BRS.