Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

285
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
285
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

319
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
319
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

822
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
822
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

316
Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
316
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

716
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
716
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

403
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
403

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction Notice to "The Protective Effect of Superoxide Dismutase Mimetic M40401 on Balloon Injury-Related Neointima Formation: Role of the Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1" J Pharmacol Exp Ther 311 (2004) 44-50.

The Journal of pharmacology and experimental therapeutics·2026
Same author

Epitranscriptomic signatures in blood: emerging biomarkers for diagnosis of diabetes and its complications.

Frontiers in cell and developmental biology·2025
Same author

Corrigendum to "The effect of peroxynitrite decomposition catalyst MnTBAP on aldehyde dehydrogenase-2 nitration by organic nitrates: Role in nitrate tolerance" [Pharmacol. Res. 89 (2014) 29-35].

Pharmacological research·2025
Same author

Clinical characteristics, therapy and outcome of bloodstream infections caused by vancomycin-resistant enterococci: a multicentre clinical experience.

The Journal of antimicrobial chemotherapy·2025
Same author

A high-throughput screening identifies MCM chromatin loading inhibitors targeting cells with increased replication origins.

iScience·2024
Same author

HIF-1α limits myocardial infarction by promoting mitophagy in mouse hearts adapted to chronic hypoxia.

Acta physiologica (Oxford, England)·2024

Related Experiment Video

Updated: Jan 3, 2026

Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

39.9K

Gender-Related Differences in Atherosclerosis.

Pankaj Mathur1, Bohuslav Ostadal, Francesco Romeo

  • 1Cardiovascular Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, 4301 West Markham St., Little Rock, AR, 72205, USA, PMathur@uams.edu.

Cardiovascular Drugs and Therapy
|May 27, 2015
PubMed
Summary
This summary is machine-generated.

Estrogen

More Related Videos

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

16.7K
Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 7, 2013

14.4K

Related Experiment Videos

Last Updated: Jan 3, 2026

Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

39.9K
A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

16.7K
Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
06:43

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

Published on: December 7, 2013

14.4K

Area of Science:

  • Cardiovascular Science
  • Endocrinology
  • Vascular Biology

Background:

  • Atherosclerotic cardiovascular disease (CVD) is a major global health concern.
  • Estrogen's protective role in premenopausal women against CVD is complex and not fully understood.
  • Hormone replacement therapy has yielded inconclusive results regarding CVD event reduction.

Purpose of the Study:

  • To explore the intricate relationship between vascular biology, estrogen hormones, and cardiovascular disease.
  • To investigate gender-specific differences in atherosclerosis pathophysiology.
  • To identify potential therapeutic targets for improving CVD treatment in women.

Main Methods:

  • Review of existing research on estrogen's effects on vascular endothelial function.
  • Analysis of gender-related differences in markers like GPER, lipoprotein A, TLRs, and leucocyte-platelet aggregates.
  • Examination of the role of hormones and tissue factors in vascular health.

Main Results:

  • Estrogen's protective effect against CVD is more complex than previously assumed.
  • Significant gender-related differences exist in the pathophysiology of atherosclerosis.
  • Hormones and tissue factors play a crucial role in maintaining vascular endothelial function.

Conclusions:

  • A deeper understanding of atherosclerosis pathophysiology, particularly gender-specific mechanisms, is essential.
  • Identifying these differences can lead to improved, evidence-based treatments for cardiovascular disease in women.
  • Further research into hormonal and tissue factors is warranted to advance women's cardiovascular health.