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Radiation therapy for locally advanced pancreatic adenocarcinoma: a therapeutic option which should not be forgotten. Letter to the Editor regarding: "Pancreatic cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up" by Huguet et al.

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Is neoadjuvant folfox an effective treatment only in a very selected favorable subgroup of locally advanced rectal cancer?

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[Informed consent in radiotherapy care].

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Indication of radiotherapy for de novo metastatic cancer. The « Recommendations » Commission first issue.

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[Radiosensitivity settings in breast cancer].

O Lauche1, D Azria2, O Riou2

  • 1Département de radiothérapie oncologique, institut du cancer de Montpellier, 208, avenue des Apothicaires, parc Euromédecine, 34298 Montpellier cedex 5, France.

Cancer Radiotherapie : Journal De La Societe Francaise De Radiotherapie Oncologique
|May 27, 2015
PubMed
Summary

Breast cancers are highly radiosensitive to radiotherapy, reducing recurrence and mortality risks. Hypofractionated schemes and targeted therapies show promise in enhancing radiosensitivity and improving outcomes.

Keywords:
Breast cancerCancer du seinCellules souches tumoralesHypofractionated and cancer stem cellsHypofractionnementRadiosensibilitéRadiosensitivity

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Molecular Biology

Context:

  • Adjuvant radiotherapy following breast-conserving surgery significantly decreases breast cancer recurrence and mortality.
  • A boost of 16 Gy to the tumor bed enhances local control, reducing recurrence risk by 4% at 10 years.
  • Breast cancers exhibit sensitivity to radiation dose per fraction, with hypofractionated schemes showing comparable outcomes to standard irradiation.

Purpose:

  • To explore the radiosensitivity of breast cancers.
  • To investigate the impact of radiation dose, fractionation, and molecular abnormalities on treatment outcomes.
  • To identify factors influencing radioresistance, such as HER1/HER2 overexpression and tumor stem cells.

Summary:

  • Breast cancers are highly radiosensitive, with adjuvant radiotherapy reducing recurrence and mortality. Hypofractionated irradiation and dose escalation improve local control.
  • The alpha/beta (α/β) ratio for breast cancer is estimated between 2.2 and 4.4 Gy.
  • Molecular abnormalities (HER1, HER2 overexpression) and tumor stem cells contribute to radioresistance, but targeted therapies can enhance radiosensitivity.

Impact:

  • Understanding breast cancer radiosensitivity is crucial for optimizing radiotherapy strategies.
  • Targeted therapies blocking HER1 and HER2 receptors can overcome radioresistance.
  • Future research into genetic abnormalities may identify new radiosensitivity markers for personalized treatment.