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Measurement of Apolipoprotein B May Predict Acute Coronary Syndrome in Hyper-triglyceridemic Young Population

M A Bari1, G P Aditya, A S Bhuiyan

  • 1Dr Md Abdul Bari, Associate Professor, Department of Cardiology, Mymensingh Medical College (MMC), Mymensingh, Bangladesh;

Mymensingh Medical Journal : MMJ
|May 27, 2015
PubMed

Insights

Apolipoprotein B (ApoB) levels are significantly associated with acute coronary syndrome in young, hyper-triglyceridemic individuals in Bangladesh. Measuring ApoB may help predict cardiac risk in this population.

Area of Science:

  • Cardiology
  • Biochemistry
  • Public Health

Background:

  • Hyper-triglyceridemia (HTG) is a risk factor for cardiovascular disease.
  • Acute coronary syndrome (ACS) in young individuals requires effective risk prediction tools.
  • Apolipoprotein B (ApoB) is implicated in atherogenesis.

Purpose of the Study:

  • To measure apolipoprotein B (ApoB) levels in young hyper-triglyceridemic (HTG) individuals in Bangladesh.
  • To assess the association between ApoB levels and the risk of acute coronary syndrome (ACS).
  • To evaluate ApoB as a potential predictor of ACS in HTG young people.

Main Methods:

  • A case-control study involving 50 young patients (18-45 years) with a first ACS event and 50 age/sex-matched healthy controls.
  • Participants were recruited from Mymensingh Medical College Hospital between June 2009 and May 2010.
  • Apolipoprotein B (ApoB) and triglyceride levels were measured.

Main Results:

  • Twenty percent of ACS cases and 21% of controls had hyper-triglyceridemia (HTG).
  • Among HTG individuals, 90% of cases and 57.1% of controls exhibited hyper-ApoB.
  • A significant association was found between ApoB levels and ACS risk in HTG young people.

Conclusions:

  • Apolipoprotein B (ApoB) is a significant independent determinant for acute coronary syndrome (ACS) in young, hyper-triglyceridemic individuals.
  • ApoB measurement can serve as an alternative tool for predicting ACS risk.
  • Early risk assessment using ApoB may aid in managing cardiovascular health in young HTG populations.

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