Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Menopause01:28

Menopause

5.2K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
5.2K
Neural Regulation01:37

Neural Regulation

45.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
45.1K
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

2.4K
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
2.4K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

2.0K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
2.0K
Oogenesis02:07

Oogenesis

71.5K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
71.5K
Psychosexual Stages of Personality: Latency01:16

Psychosexual Stages of Personality: Latency

1.5K
Following the phallic stage in Freud's theory of psychosexual development, children enter a phase called the latency period, which lasts from approximately six to twelve years of age. Unlike earlier stages, where sexual impulses played a central role, Freud believed these impulses are repressed during the latency period, becoming part of the unconscious. This stage is often described as a time of psychological calm after the turbulence of the phallic stage.
The latency period is not...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thiamine Deficiency and Neuroinflammation Are Important Contributors to Alcohol Use Disorder.

Pathophysiology : the official journal of the International Society for Pathophysiology·2025
Same author

Characterizing Kupffer Cell Production of CD5 Antigen-Like and Its Function on Regulating Migration of Natural Killer T Cells.

The American journal of pathology·2025
Same author

Proinflammatory macrophages release CXCL5 to regulate T cell function and limit effects of αPD-1 in steatosis-driven liver cancer.

JHEP reports : innovation in hepatology·2025
Same author

Dihydromyricetin supplementation improves ethanol-induced lipid accumulation and inflammation.

Frontiers in nutrition·2023
Same author

Using the Cyclotide Scaffold for Targeting Biomolecular Interactions in Drug Development.

Molecules (Basel, Switzerland)·2022
Same author

Modulation of hepatic amyloid precursor protein and lipoprotein receptor-related protein 1 by chronic alcohol intake: Potential link between liver steatosis and amyloid-β.

Frontiers in physiology·2022

Related Experiment Video

Updated: Apr 12, 2026

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model
05:32

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Published on: August 11, 2023

2.7K

Perimenopause as a neurological transition state.

Roberta D Brinton1, Jia Yao1, Fei Yin1

  • 1Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, CA 90089, USA.

Nature Reviews. Endocrinology
|May 27, 2015
PubMed
Summary

Perimenopause significantly impacts neurological health, causing symptoms due to disrupted estrogen-regulated brain systems. Understanding this estrogen receptor-brain metabolism link offers opportunities for preventing neurodegenerative diseases.

More Related Videos

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

2.7K
A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
14:26

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

Published on: April 7, 2014

16.4K

Related Experiment Videos

Last Updated: Apr 12, 2026

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model
05:32

Author Spotlight: Investigating the Relationship Between FSH and Pathophysiological Changes in Perimenopausal Women - Insights from a Mouse Model

Published on: August 11, 2023

2.7K
Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
05:44

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice

Published on: October 13, 2023

2.7K
A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
14:26

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice

Published on: April 7, 2014

16.4K

Area of Science:

  • Neuroscience
  • Endocrinology
  • Women's Health

Background:

  • Perimenopause is a reproductive transition with predominantly neurological symptoms.
  • These symptoms indicate disruptions in estrogen-regulated brain systems affecting cognition, sleep, and thermoregulation.
  • Estrogen is crucial for brain energy metabolism via estrogen receptors.

Purpose of the Study:

  • To review the neurological symptoms of perimenopause.
  • To explore the relationship between estrogen receptors, brain metabolism, and neurological dysfunction.
  • To highlight the potential of perimenopause as a window for neuroprotection.

Main Methods:

  • Literature review focusing on perimenopause, neurological symptoms, estrogen signaling, and brain metabolism.
  • Analysis of the role of estrogen receptors in regulating brain energy.
  • Examination of the link between estrogen receptor network uncoupling and hypometabolic states.

Main Results:

  • Perimenopausal neurological symptoms arise from disruptions in estrogen-regulated systems.
  • Estrogen receptor network uncoupling from the brain's bioenergetic system can lead to hypometabolism and neurological dysfunction.
  • This hypometabolic state may increase the risk for later-life neurodegenerative diseases.

Conclusions:

  • Neurological symptoms are central to the perimenopausal transition.
  • Dysfunctional estrogen receptor signaling impairs brain metabolism, contributing to neurological issues.
  • Interventions during perimenopause targeting estrogen-brain metabolism could prevent future neurodegeneration.