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Cyclodextrin complexes for treatment improvement in infectious diseases
Julieta C Imperiale1, Alejandro D Sosnik
12National Science Research Council (CONICET), Buenos Aires, Argentina.
Nanomedicine (London, England)
|May 27, 2015
Summary
Cyclodextrins (CDs) enhance antimicrobial drugs with poor properties, improving their effectiveness against infectious diseases. This review covers CD applications, administration routes, and market-ready complexes for treating infections.
Area of Science:
- Pharmaceutical Sciences
- Medicinal Chemistry
- Drug Delivery
Background:
- Infectious diseases pose a significant global health burden.
- Many antimicrobial drugs suffer from poor biopharmaceutical properties, limiting their therapeutic efficacy.
- Cyclodextrins (CDs) are cyclic oligosaccharides with unique hydrophilic and hydrophobic characteristics.
Purpose of the Study:
- To review the application of cyclodextrins (CDs) in formulating anti-infective agents.
- To discuss various administration routes for drug/CD complexes.
- To provide an update on commercially available CD-based treatments for infectious diseases.
Main Methods:
- Literature review of cyclodextrin applications in anti-infective drug formulation.
- Analysis of drug/cyclodextrin complexation strategies.
- Survey of administration routes and marketed products.
Main Results:
- Cyclodextrins significantly improve drug stability, solubility, dissolution rate, and bioavailability.
- Drug/CD complexes offer versatile administration routes for anti-infective agents.
- Several cyclodextrin-based anti-infective formulations are available on the market.
Conclusions:
- Cyclodextrin complexation is a valuable strategy to overcome the limitations of antimicrobial drugs.
- The use of CDs enhances the therapeutic potential of anti-infective agents.
- Further development of CD-based formulations holds promise for combating infectious diseases.
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