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Updated: Apr 12, 2026

Novel RNA-Binding Proteins Isolation by the RaPID Methodology
Published on: September 30, 2016
Ribosome-inactivating and related proteins
Joachim Schrot1, Alexander Weng2, Matthias F Melzig3
1Institute of Pharmacy, Freie Universitaet Berlin, Koenigin-Luise-Str. 2 + 4, 14195 Berlin, Germany. joachim.schrot@fu-berlin.de.
This review summarizes plant ribosome-inactivating proteins (RIPs), which are toxins acting as N-glycosidases. It proposes a unified classification for RIPs and related proteins outside classical types.
Area of Science:
- Biochemistry
- Molecular Biology
- Plant Science
Background:
- Ribosome-inactivating proteins (RIPs) are plant-derived toxins functioning as N-glycosidases.
- RIPs are traditionally classified into type 1 and type 2.
- Some RIPs and related proteins defy classical categorization due to structural or functional variations.
Purpose of the Study:
- To present the current state of knowledge on plant RIPs.
- To propose a unified nomenclature and classification system for all RIPs and related proteins.
- To address the lack of a standardized classification for these molecules.
Main Methods:
- Literature review of known plant RIPs.
- Analysis of structural and functional diversity among RIPs.
- Development of a proposed classification framework.
Main Results:
- Comprehensive overview of identified plant RIPs.
- Identification of RIPs and related proteins that do not fit type 1 or type 2 classification.
- A suggested framework for unifying RIP classification.
Conclusions:
- A unified classification system is needed for plant RIPs and related proteins.
- The proposed system aims to encompass all known variants.
- Standardizing nomenclature will facilitate future research in the field.
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