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Rous Sarcoma Virus (RSV) and Cancer

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model

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Primary renal myxofibrosarcoma.

José-Fernando Val-Bernal¹, M Rosa García-González², Marta Mayorga¹

¹Department of Anatomical Pathology, Marqués de Valdecilla University Hospital, Medical Faculty, University of Cantabria and IDIVAL, Santander, Spain.

Pathology, Research and Practice

|May 27, 2015

Summary

This case report details the first known instance of myxofibrosarcoma (MFS), a rare soft tissue tumor, originating in the kidney. Early diagnosis and radical surgery are crucial for managing this aggressive malignancy.

Keywords:

Immunohistochemistry Kidney Myxofibrosarcoma Sarcoma

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Area of Science:

Oncology
Pathology
Surgical Oncology

Background:

Kidney sarcomas are rare, comprising only 1% of malignant renal tumors.
Myxofibrosarcoma (MFS) is an uncommon soft tissue tumor typically found in the extremities.

Observation:

A 70-year-old woman presented with confusion due to hypertensive encephalopathy, revealing a large right renal mass.
Histopathology showed a 15-cm pleomorphic, myxoid tumor with specific immunohistochemical markers (vimentin, bcl2, CD34, CD99, AMACR).

Findings:

The renal tumor was diagnosed as myxofibrosarcoma (MFS) grade 2.
This represents the first documented case of MFS arising from the kidney.

Implications:

MFS can exceptionally arise from the kidney, necessitating inclusion in differential diagnoses of renal masses.
Radical surgery is the primary treatment, with long-term follow-up essential due to recurrence and metastasis risks.