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Multiple sclerosis in India: An institutional study
Ankit Singhal1, Rohit Bhatia1, M V Padma Srivastava1
1Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Background:
Few population based studies on multiple sclerosis have been published from India. There is an increasing demand to establish a nationwide MS registry in India especially in view of the percieved increased incidence and prevalence.
Objectives:
To create a registry data base for all MS patients presenting at our institute and understand the disease characteristics in our population and compare them with the published reports from the west.
Methods:
MS was diagnosed on the basis of clinical and imaging features (Revised McDonald׳s criteria 2010). Demographics, clinical data, treatment details and disease behavior were recorded over a follow up of one year. Descriptive analyses was performed.
Results:
101 patients (61 females) were recruited in the study period from June 2011 to December 2012. Mean age of the patients at the time of presentation was 33.3±9.2 years and mean duration of illness was 5.98±4.95. 68.4% patients had RRMS, 16.8% had SPMS whereas 14.8% patients had PPMS. Site(s) involved in first relapse was spinal cord in 43.7% patients followed by brainstem 25.3% and optic nerve in 24.1% patients. Mean number of relapses were 3.26±2.026. Mean EDSS at the time of presentation was 3.20±2.11. Overall, 55.44% patients took DMT at some point during their course of disease. No significant differences were observed between our patient characteristics when compared to publications from west.
Conclusion:
Demographic data in the present study are comparable to those reported in population-based epidemiological studies from west. A nationwide registry network will help establish stronger data on incidence, prevalence and disease profile of MS in India.
Insights
This study establishes a multiple sclerosis (MS) patient registry in India, finding demographic data comparable to Western populations. A nationwide registry is crucial for understanding MS incidence and prevalence in India.
Area of Science:
- Neurology
- Epidemiology
- Clinical Research
Background:
- Limited population-based studies on multiple sclerosis (MS) exist in India.
- Growing demand for a national MS registry due to perceived increases in incidence and prevalence.
- Understanding MS disease characteristics in the Indian population is essential.
Purpose of the Study:
- To establish a registry database for MS patients at the institute.
- To analyze the characteristics of MS in the Indian population.
- To compare Indian MS patient data with international reports.
Main Methods:
- Diagnosis of MS based on Revised McDonald criteria (2010).
- Collection of demographic, clinical, treatment, and disease behavior data.
- Descriptive analysis of data over a one-year follow-up.
Main Results:
- 101 MS patients (61 female) recruited; mean age 33.3 years.
- Relapsing-remitting MS (RRMS) was most common (68.4%).
- Spinal cord involvement in the first relapse (43.7%) and comparable characteristics to Western populations.
Conclusions:
- Demographic data of Indian MS patients align with Western epidemiological studies.
- A nationwide MS registry is vital for robust data on incidence, prevalence, and disease profiles in India.
- Further research and registry establishment are recommended for comprehensive MS understanding in India.
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