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Related Experiment Video

Updated: Apr 12, 2026

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

Selenium and preeclampsia: A global perspective.

J Vanderlelie¹, A V A Perkins¹

¹School of Medical Science, Griffith Health Institute, Griffith University, Southport, Queensland, Australia.

Pregnancy Hypertension

|May 27, 2015

Summary

Low selenium levels are linked to preeclampsia, a pregnancy disorder. Higher selenium status globally correlates with reduced preeclampsia incidence, suggesting supplementation benefits.

Keywords:

Global nutrition Preeclampsia Selenium

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Area of Science:

Obstetrics and Gynecology
Nutritional Science
Biochemistry

Background:

Preeclampsia is a pregnancy complication linked to oxidative stress.
Selenium is crucial for antioxidant synthesis, and lower levels are observed in preeclamptic women.

Purpose of the Study:

To investigate the global correlation between selenium status and preeclampsia incidence.
To determine if selenium sufficiency is associated with reduced preeclampsia rates.

Main Methods:

Systematic review of peer-reviewed articles reporting national preeclampsia incidence and selenium levels (intake, plasma/serum concentrations).
Data compiled from 45 regions, covering over 6.4 million births across continents.
Statistical analysis, including Pearson correlation, to assess the relationship between selenium concentration and preeclampsia incidence.

Main Results:

A significant negative correlation (r=-0.604) was found between plasma selenium concentration and preeclampsia incidence.
Countries with selenium sufficiency (serum/plasma levels ⩾95μg/L) showed significantly lower preeclampsia incidence (P=0.0007).
Preeclampsia incidence decreased significantly in New Zealand and Finland following government-led increases in selenium levels.

Conclusions:

The study supports the hypothesis that adequate selenium status is associated with reduced preeclampsia incidence.
Findings suggest that selenium supplementation could be a beneficial strategy for mitigating oxidative stress in at-risk pregnancies.
Global mapping reveals geographical variations in selenium status and their potential impact on preeclampsia prevalence.