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Modified Annexin V/Propidium Iodide Apoptosis Assay For Accurate Assessment of Cell Death
Published on: April 24, 2011
Regulated cell death in diagnostic histopathology
Faruk Skenderi1, Semir Vranic, Ivan Damjanov
1Department of Pathology, University of Sarajevo Clinical Center, Sarajevo, Bosnia and Herzegovina.
Abstract:
Regulated cell death (RCD) is a controlled cellular process, essential for normal development, tissue integrity and homeostasis, and its dysregulation has been implicated in the pathogenesis of various conditions including developmental and immunological disorders, neurodegenerative diseases, and cancer. In this review, we briefly discuss the historical perspective and conceptual development of RCD, we overview recent classifications and some of the key players in RCD; finally we focus on current applications of RCD in diagnostic histopathology.
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