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Modified Annexin V/Propidium Iodide Apoptosis Assay For Accurate Assessment of Cell Death
Published on: April 24, 2011
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Regulated cell death in diagnostic histopathology
Faruk Skenderi1, Semir Vranic, Ivan Damjanov
1Department of Pathology, University of Sarajevo Clinical Center, Sarajevo, Bosnia and Herzegovina.
The International Journal of Developmental Biology
|May 27, 2015
Summary
Regulated cell death (RCD) is a vital cellular process. Understanding RCD and its role in diseases like cancer and neurodegeneration is crucial for diagnostic histopathology.
Area of Science:
- Cellular Biology
- Pathology
Background:
- Regulated cell death (RCD) is a fundamental cellular process crucial for development, tissue homeostasis, and immunity.
- Dysregulation of RCD is linked to various diseases, including developmental disorders, immune conditions, neurodegenerative diseases, and cancer.
Purpose of the Study:
- To provide a historical perspective and conceptual evolution of regulated cell death.
- To review current classifications and key molecular players involved in RCD.
- To highlight the applications of RCD in diagnostic histopathology.
Main Methods:
- Literature review of historical perspectives on RCD.
- Overview of recent RCD classifications.
- Discussion of key molecular mechanisms and mediators of RCD.
- Analysis of RCD's role in diagnostic histopathology.
Main Results:
- RCD encompasses diverse, evolutionarily conserved mechanisms.
- Recent advancements have refined RCD classification and identified critical molecular players.
- RCD plays a significant role in the pathogenesis of numerous diseases.
- RCD provides valuable insights and tools for diagnostic histopathology.
Conclusions:
- Regulated cell death is a complex and essential biological process with broad implications.
- Continued research into RCD mechanisms and classifications enhances our understanding of disease.
- The application of RCD knowledge in diagnostic histopathology is expanding and vital for disease diagnosis and management.
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