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Published on: September 20, 2021
Acyclovir in pityriasis rosea: An observer-blind, randomized controlled trial of effectiveness, safety and
Anupam Das1, Amrita Sil2, Nilay Kanti Das1
1Department of Dermatology, Medical College, Institute of Postgraduate Education and Research, Kolkata, West Bengal, India.
Background:
Pityriasis rosea (PR) is an acute inflammatory dermatosis. The association of human herpes virus 6 and 7 suggests the utility of use of antiviral agents in this disease.
Aims And Objectives:
To evaluate the effectiveness and safety of acyclovir in the treatment of PR.
Methods:
An observer-blind, randomized (1:1), parallel group, add-on trial was conducted on 24 adult patients with PR. Subjects of both Group A and B received the standard of care in the form of cetirizine 10 mg OD and calamine. Group A in addition received acyclovir 400 mg tablets thrice daily for 7 days. Both groups were followed up for four consecutive weeks for assessment of effectiveness and adverse events.
Results:
Group A complained of significantly fewer new lesions than Group B (P = 0.046). A complete response was obtained in all patients of Group A and 83% patients of Group B at the end of the follow up period. There was significant reduction in both lesional score and pruritus at second week follow-up in Group A and third week follow-up in Group B (P < 0.05). Minor adverse effects were observed in both treatment arms.
Conclusion:
Acyclovir offered rapid resolution of clinical severity of PR from second week onwards without significantly increased adverse events as compared to supportive therapy alone.
