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Updated: Apr 11, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Tumor with the features of both squamous cell carcinoma and melanoma (melanocarcinoma)
Elise Kochoumian1, Viktoryia Kazlouskaya2, Aaron Mangold3
1New York College of Osteopathic Medicine, NY, USA.
Abstract:
Combined tumors of malignant melanoma (MM) and squamous cell carcinoma (SCC) are extremely rare and have unknown biological potential. Different theories of their development, including collision and dual/divergent differentiation, are proposed. Although some observations suggest an indolent course for such tumors, a case of MM metastasis was reported in a patient who initially presented with a combined MM-SCC tumor. Re-excisions of such tumors may show MM in situ and should be treated accordingly. Herein we present another case of a combined MM-SCC tumor in a 78 male patient with lentigo maligna seen after complete re-excision of the tumor.
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