Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Prevalence and Incidence01:08

Prevalence and Incidence

2.4K
In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
2.4K
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

1.5K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.5K
Factors Affecting Illness01:18

Factors Affecting Illness

5.7K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
5.7K
Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

63
Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable...
63
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

2.3K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
2.3K
Toxidromes: Clinical Features01:30

Toxidromes: Clinical Features

150
Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...
150

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enriching African genome representation through the AGenDA project.

Nature·2026
Same author

Genetic disorders in Arabs as for OMIM.

Saudi medical journal·2016
Same author

Clinical and molecular investigation of Buschke-Fischer-Brauer in consanguineous Tunisian families.

Journal of the European Academy of Dermatology and Venereology : JEADV·2016
Same author

Sanjad-Sakati syndrome in a Tunisian child.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2015
Same author

Clinical, genealogical and molecular investigation of the xeroderma pigmentosum type C complementation group in Tunisia.

The British journal of dermatology·2015
Same author

Molecular characterization of piebaldism in a Tunisian family.

Pathologie-biologie·2015

Related Experiment Video

Updated: Apr 11, 2026

Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae
06:04

Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae

Published on: February 24, 2023

3.0K

Comorbidity in the Tunisian population.

L Romdhane1,2, O Messaoud1, Y Bouyacoub1

  • 1Biomedical Genomics and Oncogenetics Laboratory, Institut Pasteur de Tunis, Université Tunis El Manar, Tunis, Tunisia.

Clinical Genetics
|May 27, 2015
PubMed
Summary

Genetic diseases, including over 400 disorders, are a public health concern in Tunisia, influenced by consanguinity. This study reports 75 genetic disease associations (comorbidity) in Tunisian families, highlighting challenges for genetic counseling.

Keywords:
Tunisiacomorbidityconsanguinityfounder mutationgenetic counselinggenetic diseasegenetic mappingprenatal diagnosis

More Related Videos

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
23:06

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

Published on: August 11, 2008

19.8K
Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

15.5K

Related Experiment Videos

Last Updated: Apr 11, 2026

Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae
06:04

Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae

Published on: February 24, 2023

3.0K
The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis
23:06

The MODS method for diagnosis of tuberculosis and multidrug resistant tuberculosis

Published on: August 11, 2008

19.8K
Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
06:55

Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index

Published on: January 8, 2020

15.5K

Area of Science:

  • Genetics
  • Public Health
  • Medical Genetics

Background:

  • Genetic diseases pose a significant public health challenge in Tunisia, with over 400 identified disorders.
  • Demographic, economic, and social factors, particularly consanguinity, influence the prevalence and distribution of these diseases.
  • Existing information on genetic disease associations (comorbidity) in the Tunisian population is fragmented.

Purpose of the Study:

  • To centralize information on genetic disease associations (comorbidity) in the Tunisian population.
  • To highlight the occurrence of comorbidity in consanguineous populations.
  • To draw the attention of clinicians and researchers to the complexities of genetic counseling and prenatal diagnosis in such cases.

Main Methods:

  • Review and compilation of reported genetic disease associations within Tunisian families.
  • Analysis of the role of consanguinity in comorbid associations.
  • Identification of founder and private mutations responsible for primary and associated diseases.

Main Results:

  • Seventy-five distinct genetic disease associations (comorbidity) were identified among Tunisian families.
  • Consanguinity was a noted factor in 39 of these comorbid associations.
  • Twenty-one founder and 11 private mutations were found to cause 34 primary diseases and 13 associated diseases.

Conclusions:

  • Genetic disease comorbidity is a significant phenomenon in the Tunisian population, particularly in consanguineous families.
  • The presence of comorbidity complicates genetic counseling and prenatal diagnosis, even when specific mutations are known.
  • Centralizing data on genetic disease associations is crucial for improving clinical management and research in Tunisia.