Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Macrophages and erythrocytes].

M Yoshida, E Kajii, S Kitagawa

    [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
    |August 1, 1989
    PubMed
    Summary

    Senescent red blood cells (SRBCs) are cleared by macrophages via lectin-like and complement receptors. Tumor necrosis factor (TNF) enhances this clearance, suggesting a mechanism for managing damaged red blood cells during inflammation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A rare case of Lemierre`s syndrome caused by Porphyromonas asaccharolytica.

    Infection·2013
    Same author

    Large scale replication analysis of loci associated with lipid concentrations in a Japanese population.

    Journal of medical genetics·2009
    Same author

    RHC/c genotyping based on polymorphism in the promoter region of the RHCE gene.

    Legal medicine (Tokyo, Japan)·2003
    Same author

    Genotyping of TF*Dchi allele in human transferrin polymorphism.

    Legal medicine (Tokyo, Japan)·2003
    Same author

    cDNA cloning, mapping and polymorphism of the porcine Rhesus (RH) gene.

    Animal genetics·2003
    Same author

    A novel mutation in the RHD gene in Japanese individuals with weak D, encoding an amino acid change in the 11th transmembranous domain of the RhD protein.

    Vox sanguinis·2003

    Area of Science:

    • Immunology
    • Hematology

    Context:

    • Senescent red blood cells (SRBCs) are cleared by the reticuloendothelial system.
    • Understanding this clearance mechanism is crucial for hematological health and inflammatory conditions.

    Purpose:

    • To investigate the mechanisms of senescent red blood cell (SRBC) clearance by macrophages.
    • To explore the role of serum factors and tumor necrosis factor (TNF) in erythrophagocytosis.

    Summary:

    • A novel phagocytosis assay revealed significantly higher uptake of SRBCs and Vibrio cholera neuraminidase (VCN)-treated RBCs by autologous macrophages compared to unfractionated RBCs.
    • VCN-treated RBC phagocytosis was enhanced by fresh autologous serum, suggesting lectin-like and complement receptor involvement on macrophages.
    • Tumor necrosis factor (TNF) at low concentrations enhanced VCN-treated RBC phagocytosis, indicating its role in activating the reticuloendothelial system for damaged RBC clearance.

    Impact:

    • Elucidates the molecular mechanisms of red blood cell clearance.
    • Provides insights into the pathogenesis of anemia associated with acute inflammation.
    • Suggests potential therapeutic targets for modulating red blood cell turnover.

    Related Experiment Videos