Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

7.0K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
7.0K
Bone Disorders01:29

Bone Disorders

8.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.7K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

9.3K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
9.3K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

4.3K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
4.3K
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

905
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
905
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

5.6K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Effect of Media Campaigns, Patient Characteristics, and Presenting Symptoms on Prehospital Delay in Myocardial Infarction Patients: A Prospective Cohort Study.

Heart, lung & circulation·2018
Same author

Initial evaluation of thyroid dysfunction - Are simultaneous TSH and fT4 tests necessary?

PloS one·2018
Same author

Declining rates of sterilisation reversal procedures in western Australian women from 1990 to 2008: the relationship with age, hospital type and government policy changes.

BMC women's health·2017
Same author

Thyroid Function Tests in the Reference Range and Fracture: Individual Participant Analysis of Prospective Cohorts.

The Journal of clinical endocrinology and metabolism·2017
Same author

The log TSH-free T4 relationship in a community-based cohort is nonlinear and is influenced by age, smoking and thyroid peroxidase antibody status.

Clinical endocrinology·2016
Same author

Declining rates of sterilization procedures in Western Australian women from 1990 to 2008: the relationship with age, hospital type, and government policy changes.

Fertility and sterility·2016

Related Experiment Video

Updated: Apr 11, 2026

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
09:02

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Published on: January 31, 2025

1.8K

Subclinical thyroid dysfunction and fracture risk: a meta-analysis.

Manuel R Blum1, Douglas C Bauer2, Tinh-Hai Collet3

  • 1Department of General Internal Medicine, Inselspital, Bern University Hospital, Bern, Switzerland.

JAMA
|May 27, 2015
PubMed
Summary
This summary is machine-generated.

Subclinical hyperthyroidism, not hypothyroidism, increases fracture risk, especially hip fractures. Lower thyroid-stimulating hormone (TSH) levels correlate with higher fracture rates, warranting further investigation into treatment efficacy.

More Related Videos

Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

2.7K
Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

8.7K

Related Experiment Videos

Last Updated: Apr 11, 2026

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
09:02

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Published on: January 31, 2025

1.8K
Assessment of Bone Fracture Healing Using Micro-Computed Tomography
12:04

Assessment of Bone Fracture Healing Using Micro-Computed Tomography

Published on: December 9, 2022

2.7K
Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
07:12

Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model

Published on: September 28, 2017

8.7K

Area of Science:

  • Endocrinology
  • Bone Health
  • Epidemiology

Background:

  • Subclinical thyroid dysfunction's link to fractures is not well-established.
  • Clinical trials investigating this association are lacking.

Purpose of the Study:

  • To determine the association between subclinical thyroid dysfunction and fractures.
  • Specifically examining hip, non-spine, spine, and any fracture types.

Main Methods:

  • A systematic review and meta-analysis of prospective cohort studies.
  • Data from 13 cohorts (70,298 participants) were analyzed.
  • Thyroid function categorized into euthyroidism, subclinical hyperthyroidism, and subclinical hypothyroidism based on TSH levels.

Main Results:

  • Subclinical hyperthyroidism was associated with increased hip fracture risk (HR 1.36) and any fracture risk (HR 1.28).
  • Very low TSH levels (<0.10 mIU/L) showed a significantly higher risk for hip, any, and spine fractures.
  • No significant association was found between subclinical hypothyroidism and fracture risk.

Conclusions:

  • Subclinical hyperthyroidism is linked to a higher risk of fractures, particularly hip fractures.
  • The risk is more pronounced with lower TSH levels and in endogenous subclinical hyperthyroidism.
  • Further research is needed to explore if treating subclinical hyperthyroidism can mitigate fracture risk.