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The peptaibiotics database--a comprehensive online resource.

Nora K N Neumann1, Norbert Stoppacher1,2, Susanne Zeilinger3

  • 1Center for Analytical Chemistry, Department of Agrobiotechnology IFA-Tulln, University of Natural Resources and Life Sciences, Vienna (BOKU), Konrad Lorenz Straße 20, A-3430 Tulln, (phone: +43-2272-66280).

Chemistry & Biodiversity
|May 27, 2015
PubMed
Summary

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This summary is machine-generated.

The Peptaibiotics Database (PDB) is a new online resource for fungal non-ribosomal peptides containing Aib. It updates and expands existing data, offering enhanced search functionalities for the scientific community.

Area of Science:

  • Biochemistry
  • Mycology
  • Bioinformatics

Background:

  • Non-ribosomal peptides, particularly peptaibiotics, are crucial in fungal biology and have therapeutic potential.
  • Existing databases for peptaibiotics require updates and expansion to encompass newly discovered sequences.
  • Accurate and accessible data on fungal peptaibiotics is essential for research in drug discovery and molecular biology.

Purpose of the Study:

  • To develop and launch the Peptaibiotics Database (PDB), a comprehensive online resource for Aib-containing non-ribosomal fungal peptides.
  • To extend and update the 'Comprehensive Peptaibiotics Database' with newly identified sequences.
  • To provide a freely accessible platform with enhanced search capabilities for the scientific community.

Main Methods:

Keywords:
Non-ribosomal peptidesOnline databasesPeptaibolsPeptide antibioticsPeptides

Related Experiment Videos

  • Compiled 1,297 peptabiotic sequences from scientific literature, including 235 new sequences from January 2013 to June 2014.
  • Integrated new sequences into an updated database, building upon the 'Comprehensive Peptaibiotics Database'.
  • Developed an administrative interface for content maintenance and implemented advanced search functionalities, including sequence motif searches.

    • Main Results:

    • The Peptaibiotics Database (PDB) now contains 1,297 peptabiotic sequences.
    • Significantly enhanced search options compared to previous repositories, allowing for complex query combinations.
    • Established a public repository with features for easy data submission and correction.

    Conclusions:

    • The PDB serves as a valuable, up-to-date public resource for fungal peptaibiomics research.
    • The database facilitates easier access to and analysis of peptabiotic data, supporting future discoveries.
    • The flexible design allows for future expansion to meet the evolving needs of the peptaibiomics community.