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[Clinicopathological study on microscopic urinalysis as screening for malignant cells]
Rinsho Byori. the Japanese Journal of Clinical Pathology
|October 1, 1989
Summary
Microscopic urinalysis effectively detects malignant cells in urine, triggering cancer diagnoses in 34.1% of cases. Combining urinalysis with urinary cytology improves detection of urinary tract malignancies.
Area of Science:
- Uropathology
- Oncology
- Cytopathology
Context:
- Urinary sediment analysis is crucial for diagnosing urinary tract malignancies.
- Supravital staining aids in the detection of atypical cells in urine.
- A large-scale study evaluated diagnostic methods over two years.
Purpose:
- To assess the efficacy of microscopic urinalysis in detecting malignant cells.
- To compare the diagnostic accuracy of microscopic urinalysis with urinary cytology and histological findings.
- To determine the role of microscopic urinalysis as a screening tool for urinary tract cancers.
Summary:
- Microscopic urinalysis of 96,554 specimens identified atypical cells in 138 patients, leading to histological diagnoses of 47 cancers (34.1%), including bladder, ureter, renal pelvis, prostate, rectal, and uterine malignancies.
- For bladder cancers, microscopic urinalysis had a 43.4% positive rate, compared to 52.4% for urinary cytology, with higher positivity in high-grade cancers.
- The study found an 89.5% correspondence rate between microscopic urinalysis and urinary cytology, suggesting their combined use enhances the detection of urinary tract malignancies.
Impact:
- Microscopic urinalysis serves as a valuable initial screening tool for detecting urinary tract malignancies.
- The findings highlight the importance of integrating microscopic urinalysis with urinary cytology for improved cancer diagnosis.
- Early detection through these methods can potentially trigger timely cancer diagnoses and treatment initiation.