[Development and clinical application of ICG clearance meter]

Area of Science:

• Biomedical Engineering
• Analytical Chemistry
• Pharmacokinetics

Context:

• Accurate quantification of indocyanine green (ICG) is crucial for assessing liver function and blood flow.
• Conventional methods for measuring ICG plasma disappearance rate (PDR) can be invasive or time-consuming.
• There is a need for a more accessible and accurate method to determine ICG pharmacokinetics.

Purpose:

• To develop and validate a novel finger-piece spectrophotometry method for accurate ICG concentration measurement.
• To evaluate the correlation between the new method (XK ICG) and the conventional PDR (KICG).
• To explore the potential of this new method in revealing new aspects of ICG pharmacokinetics.

Summary:

• A new finger-piece spectrophotometry technique utilizing two-wavelength analysis was developed to determine ICG concentration.
• Seventy-eight subjects were assessed, and the ICG clearance curve demonstrated distinct patterns post-injection.
• Plasma disappearance rate (PDR) calculated by the new method (XK ICG) using least squares from 5-15 minutes showed significant correlation with the conventional KICG.

Impact:

• This method provides an accurate and potentially less invasive way to assess ICG PDR.
• The validated correlation suggests reliability for clinical and research applications.
• The technique may uncover novel insights into the pharmacokinetics of ICG, aiding in drug development and patient monitoring.