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[Cirrhotic cardiomyopathy: a brief overview]

S Marchetta, J Delwaide, R Lancellotti

    Revue Medicale De Liege
    |May 28, 2015
    PubMed

    Insights

    Cirrhotic cardiomyopathy involves heart abnormalities in patients with alcoholic cirrhosis. Early detection and understanding its complex mechanisms are crucial for managing cardiac dysfunction in these patients.

    Area of Science:

    • Cardiology
    • Hepatology
    • Internal Medicine

    Context:

    • Cardiac disorders in alcoholic cirrhosis have been recognized for over 50 years.
    • Cirrhotic cardiomyopathy was formally defined in the late 1980s.
    • It encompasses cardiac structural and functional issues in cirrhotic patients without other heart diseases.

    Purpose:

    • To define and characterize cirrhotic cardiomyopathy.
    • To outline its diagnostic methods and underlying pathophysiology.
    • To discuss current treatment limitations and future considerations.

    Summary:

    • Cirrhotic cardiomyopathy presents with impaired systolic function (especially under stress), diastolic dysfunction, and electrophysiological abnormalities.
    • Diagnosis involves electrocardiogram, echocardiography, and cardiac biomarkers like BNP.
    • Complex mechanisms include adrenergic signaling anomalies, myocyte membrane alterations, fibrosis, hypertrophy, hormonal imbalances, and ion channel dysfunction.

    Impact:

    • Highlights the need to consider cirrhotic cardiomyopathy in patients undergoing TIPS or liver transplantation.
    • Emphasizes the lack of specific treatments, making liver transplantation a potential cure.
    • Underscores the importance of recognizing and managing cardiac dysfunction in liver cirrhosis.

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