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Related Experiment Video

Updated: Apr 11, 2026

A Treatment Package without Escape Extinction to Address Food Selectivity

A Treatment Package without Escape Extinction to Address Food Selectivity

Published on: August 21, 2015

Feeding time.

Hugh D Piggins¹, David A Bechtold²

¹Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom hugh.d.piggins@manchester.ac.uk.

|May 28, 2015

Summary

This summary is machine-generated.

A gut hormone released after eating can reset the liver's internal clock. This finding reveals a new connection between digestion and the body's daily rhythms.

Keywords:

biochemistry cell biology circadian clock clock genes food resetting liver mouse per

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Area of Science:

Biochemistry
Chronobiology
Endocrinology

Background:

The liver exhibits daily rhythms crucial for metabolic regulation.
Clock genes orchestrate these circadian rhythms.
The gut-liver axis is increasingly recognized for its role in metabolic health.

Purpose of the Study:

To investigate the impact of postprandial gut hormones on hepatic clock gene expression.
To identify potential signaling pathways linking nutrient intake to liver circadian function.

Main Methods:

Analysis of gut hormone levels in response to meals.
In vivo and in vitro studies on liver cells.
Measurement of clock gene expression (e.g., Bmal1, Clock, Per, Cry) using techniques like RT-qPCR.

Main Results:

A specific gut hormone, identified post-meal, was found to significantly alter the expression patterns of key liver clock genes.
This hormonal signaling directly influences the transcription and translation of core circadian components within hepatocytes.
The effect demonstrates a rapid reset of the liver's molecular clock.

Conclusions:

Postprandial gut hormones play a direct role in regulating liver circadian rhythms.
This mechanism provides a direct link between nutrient sensing in the gut and the metabolic timing within the liver.
Targeting this gut-liver communication pathway may offer novel therapeutic strategies for circadian rhythm disorders and metabolic diseases.