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Published on: October 27, 2023
Apparent diffusion coefficient is highly reproducible on preclinical imaging systems: Evidence from a seven-center
Sabrina Doblas1, Gilberto S Almeida2, François-Xavier Blé3
1Laboratory of imaging biomarkers, UMR 1149 - CRI, Inserm, Paris Diderot University, Paris, France.
Purpose:
To evaluate between-site agreement of apparent diffusion coefficient (ADC) measurements in preclinical magnetic resonance imaging (MRI) systems.
Materials And Methods:
A miniaturized thermally stable ice-water phantom was devised. ADC (mean and interquartile range) was measured over several days, on 4.7T, 7T, and 9.4T Bruker, Agilent, and Magnex small-animal MRI systems using a common protocol across seven sites. Day-to-day repeatability was expressed as percent variation of mean ADC between acquisitions. Cross-site reproducibility was expressed as 1.96 × standard deviation of percent deviation of ADC values.
Results:
ADC measurements were equivalent across all seven sites with a cross-site ADC reproducibility of 6.3%. Mean day-to-day repeatability of ADC measurements was 2.3%, and no site was identified as presenting different measurements than others (analysis of variance [ANOVA] P = 0.02, post-hoc test n.s.). Between-slice ADC variability was negligible and similar between sites (P = 0.15). Mean within-region-of-interest ADC variability was 5.5%, with one site presenting a significantly greater variation than the others (P = 0.0013).
Conclusion:
Absolute ADC values in preclinical studies are comparable between sites and equipment, provided standardized protocols are employed.
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