Related Experiment Video
Updated: Apr 11, 2026

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine
Published on: January 30, 2020
Modelling ventricular fibrillation coarseness during cardiopulmonary resuscitation by mixed effects stochastic
Kenneth Gundersen1, Jan Terje Kvaløy2, Trygve Eftestøl1
1Department of Electrical Engineering and Computer Science, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway.
Abstract:
For patients undergoing cardiopulmonary resuscitation (CPR) and being in a shockable rhythm, the coarseness of the electrocardiogram (ECG) signal is an indicator of the state of the patient. In the current work, we show how mixed effects stochastic differential equations (SDE) models, commonly used in pharmacokinetic and pharmacodynamic modelling, can be used to model the relationship between CPR quality measurements and ECG coarseness. This is a novel application of mixed effects SDE models to a setting quite different from previous applications of such models and where using such models nicely solves many of the challenges involved in analysing the available data.
Related Concept Videos
Modeling with Differential Equations
Cardiac Output II: Effect of Stroke Volume on Cardiac Output
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
Cardiopulmonary Resuscitation III: AED Use
Disturbances in Heart Rhythm
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Cardiopulmonary Resuscitation IV: Pharmacological Management
Cardiopulmonary Resuscitation I: Adult

