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Related Concept Videos

Insulin: Dosing Regimen and Adverse Effects01:16

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Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
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Insulin Formulations: Types and Delivery01:27

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Insulin preparations are categorized by their duration of action into short-acting and long-acting types. Two strategies are used to modify insulin's absorption and pharmacokinetic profile: slowing the absorption post-subcutaneous injection, or altering human insulin's amino acid sequence or protein structure. These changes retain the insulin's ability to bind to the insulin receptor, but alter its behavior in solution or after injection.
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Metabolic States of the Body: Fasting and Starvation01:24

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During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
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Metabolic States of the Body: The Postabsorptive State01:18

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The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
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Hormones Regulating Blood Glucose01:16

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Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
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Hypoglycemia and Glucagon01:15

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Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
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Fasting in Ramadan with an insulin pump.

Jothydev Kesavadev1

  • 1Department of Diabetes, Jothydev's Diabetes Research Centre, Trivandrum, Kerala, India.

JPMA. the Journal of the Pakistan Medical Association
|May 28, 2015
PubMed
Summary

Insulin pumps help manage diabetes during Ramadan fasting by providing variable basal rates and boluses, preventing hypoglycemia and hyperglycemia. These advanced systems enhance patient quality of life and confidence while fasting.

Keywords:
Diabetic Ketoacidosis, Fasting, Hypoglycaemia, Infusion Pumps, External, Quality of life.

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Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Diabetes Management

Background:

  • Many individuals with diabetes using insulin therapies observe fasting during Ramadan.
  • Managing diabetes during Ramadan requires balancing fasting needs with maintaining safe blood glucose levels and avoiding hypoglycemia.

Purpose of the Study:

  • To evaluate the role and benefits of insulin pumps in managing diabetes for individuals observing Ramadan fasts.
  • To highlight how insulin pump technology can aid in achieving glycemic control during fasting periods.

Main Methods:

  • The study discusses the technological features of insulin pumps, including variable basal rates and customizable boluses.
  • It examines how these features can be programmed to accommodate fasting schedules and reduce the risk of glucose fluctuations.

Main Results:

  • Insulin pumps offer technological advantages like pre-programmable reduced basal rates to prevent hypoglycemia during fasting.
  • These devices help avoid both hypoglycemia and hyperglycemia, thereby preserving patients' quality of life and confidence.

Conclusions:

  • Insulin pumps are considered superior insulin delivery systems for diabetic patients fasting during Ramadan.
  • Despite cost and optimal usage prerequisites, their benefits in glycemic control and quality of life are significant.