NIG_MoG: a mouse genome navigator for exploring intersubspecific genetic polymorphisms.

Area of Science:

• Genomics
• Bioinformatics
• Comparative genomics

Background:

• The National Institute of Genetics Mouse Genome database (NIG_MoG) houses whole-genome sequence data for MSM/Ms and JF1/Ms mouse strains.
• These strains originate from the Japanese subspecies Mus musculus molossinus.
• Understanding intersubspecific genome divergence is crucial for genetic research.

Purpose of the Study:

• To provide visualized genome polymorphism information for MSM/Ms and JF1/Ms mouse strains.
• To facilitate the in silico screening of bacterial artificial chromosome (BAC) clones.
• To serve as a resource for exploring mouse genome polymorphisms and BAC clones.

Main Methods:

• The NIG_MoG database visualizes single-nucleotide polymorphisms and short insertions/deletions.
• Genome data is presented in comparison to C57BL/6J, derived from M. m. domesticus.
• In silico screening of BAC clones containing genomic DNA from MSM/Ms and C57BL/6N is supported.

Main Results:

• NIG_MoG offers intuitive visualization of genome divergence between Mus musculus subspecies.
• The database allows for easy identification of genetic variations.
• Users can efficiently screen for relevant BAC clones.

Conclusions:

• NIG_MoG is a valuable tool for researchers, particularly wet-lab biologists.
• It aids in understanding intersubspecific genome divergence in mice.
• The database supports studies on gene function and regulation using mouse genome polymorphisms and BAC clones.