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Task-related modulation of functional connectivity variability and its behavioral correlations.

Amanda Elton1, Wei Gao1

  • 1Department of Radiology and Biomedical Research Imaging Center, University of North Carolina, Chapel Hill, North Carolina.

Human Brain Mapping
|May 28, 2015
PubMed
Summary

Functional connectivity variability (FCV) decreases during tasks, suggesting mind-wandering influences brain function. This task-related decrease in FCV correlates with better performance, offering insights into brain disorders.

Keywords:
behaviorfMRIneural interconnectionsneural networkstask performance

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Brain Imaging

Background:

  • Functional connectivity variability (FCV) is increasingly studied within brain states.
  • Task-related dynamics of functional connectivity are of growing interest.
  • The interplay between task demands and FCV remains underexplored.

Purpose of the Study:

  • To investigate task-related modulation of functional connectivity variability (FCV).
  • To explore the relationship between FCV, task performance, and potential biomarkers.

Main Methods:

  • 19 subjects underwent functional magnetic resonance imaging (fMRI) during resting and task states.
  • Analysis focused on regional, network, and system-level FCV changes.
  • Correlation analysis between FCV decreases and task performance accuracy.

Main Results:

  • FCV significantly decreased during task states compared to resting states.
  • Task-induced FCV decreases were more pronounced for between-network interactions.
  • Residual FCV during tasks suggests an intrinsic physiological component.
  • Task-induced FCV decreases positively correlated with task performance accuracy.

Conclusions:

  • FCV is modulated by task demands, potentially reflecting reduced mind-wandering.
  • FCV is not exclusive to resting states and has intrinsic components.
  • Task-modulated FCV may serve as a biomarker for brain disorders and performance.