Related Experiment Video
Updated: Apr 11, 2026
07:52
Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
Published on: June 2, 2015
12.9K
Remote Ischemic Preconditioning To Reduce Contrast-Induced Nephropathy: A Randomized Controlled Trial.
T P Menting1, T B Sterenborg1, Y de Waal2
1Department of Surgery, Division of Vascular and Transplant Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Summary
Remote ischemic preconditioning (RIPC) did not prevent contrast induced nephropathy (CIN) in at-risk patients. However, RIPC showed potential benefits for those with a high risk score (Mehran score ≥11).
Area of Science:
- Nephrology
- Cardiology
- Intensive Care Medicine
Background:
- Contrast-induced nephropathy (CIN) remains a significant concern despite current preventive strategies.
- Contrast media can induce renal medulla ischemia-reperfusion injury.
- Remote ischemic preconditioning (RIPC) is a safe, non-invasive method to mitigate ischemia-reperfusion injury.
Purpose of the Study:
- To evaluate the efficacy of RIPC as an adjunct to standard preventive measures for CIN.
- To determine if RIPC reduces the incidence or severity of contrast-induced acute kidney injury in at-risk patients.
Main Methods:
- A multicenter, single-blinded, randomized controlled trial (RIPCIN study) involving 76 at-risk patients.
- Intervention group received standard hydration plus RIPC (4 cycles of 5-min ischemia/5-min reperfusion).
- Control group received standard hydration with sham preconditioning.
- Primary outcome: change in serum creatinine from baseline to 48-72 hours post-contrast.
Main Results:
- No significant difference in serum creatinine change was observed between RIPC and sham groups for the overall study population.
- CIN occurred in 4 patients (2 in each group).
- Subgroup analysis of patients with a Mehran risk score ≥11 revealed a significantly reduced serum creatinine increase in the RIPC group compared to the sham group.
Conclusions:
- RIPC, when added to standard care, did not significantly improve serum creatinine levels in patients at risk of CIN based on Dutch guidelines.
- RIPC may offer a protective benefit for patients identified as having a high or very high risk of CIN (Mehran score ≥11).
Keywords:
Acute kidney injury – pre- and post-hydrationContrast induced nephropathyRandomized controlled trialRemote ischemic preconditioningMore Related Videos
05:26Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
Published on: May 28, 2019
9.8K
07:46Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
Published on: May 9, 2013
30.4K
Related Concept Videos
01:19Imaging Studies VII: Vascular Imaging
504
DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
504
01:28Imaging Studies for Cardiovascular System V: CT
612
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
612
01:28Cardiac Catheterization I: Pre-Procedure Overview
2.8K
Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
2.8K
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
515
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
515
01:26Cardiac Catheterization IV: Nursing Management
1.2K
Nursing responsibilities before cardiac catheterization include:Assess for allergies and establish baseline health status.Before cardiac catheterization, assess the patient for allergies to contrast dye. Perform a comprehensive baseline assessment, including vital signs, heart and breath sounds, and a neurovascular assessment of the extremities, noting distal pulses, skin color, and temperature. Instruct the patient to fast for 8-12 hours before the procedure. Evaluate baseline laboratory...
1.2K
01:30Radiological Investigation I: X-ray and CT
1.6K
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
1.6K