Related Experiment Video
Updated: Apr 11, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
The epigenetic paradigm in periodontitis pathogenesis
Vamsi Lavu1, Vettriselvi Venkatesan2, Suresh Ranga Rao1
1Department of Periodontology, Faculty of Dental Sciences, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.
Abstract:
Epigenome refers to "epi" meaning outside the "genome." Epigenetics is the field of study of the epigenome. Epigenetic modifications include changes in the promoter CpG Islands, modifications of histone protein structure, posttranslational repression by micro-RNA which contributes to the alteration of gene expression. Epigenetics provides an understanding of the role of gene-environment interactions on disease phenotype especially in complex multifactorial diseases. Periodontitis is a chronic inflammatory disorder that affects the supporting structures of the tooth. The role of the genome (in terms of genetic polymorphisms) in periodontitis pathogenesis has been examined in numerous studies, and chronic periodontitis has been established as a polygenic disorder. The potential role of epigenetic modifications in the various facets of pathogenesis of periodontitis is discussed in this paper based on the available literature.
Related Concept Videos
The Oral Microbiota
Development of the Oral Microbiota
Epigenetic Regulation
X-chromosome...
Epigenetic Regulation
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Genomic Imprinting and Inheritance
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...

