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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

The epigenetic paradigm in periodontitis pathogenesis.

Vamsi Lavu¹, Vettriselvi Venkatesan², Suresh Ranga Rao¹

¹Department of Periodontology, Faculty of Dental Sciences, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India.

Journal of Indian Society of Periodontology

|May 28, 2015

Summary

Epigenetics, the study of gene expression changes without altering DNA sequence, plays a role in periodontitis. This research reviews epigenetic mechanisms in periodontitis pathogenesis.

Keywords:

Chronic periodontitis epigenetic modifications micro-RNA pathogenesis

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Area of Science:

Genetics and Molecular Biology
Oral and Dental Health

Background:

Epigenetics involves modifications like DNA methylation and histone alterations, influencing gene expression.
Gene-environment interactions are crucial in complex diseases, including periodontitis.
Periodontitis, a chronic inflammatory oral disease, is influenced by genetic factors.

Purpose of the Study:

To explore the role of epigenetic modifications in periodontitis pathogenesis.
To review current literature on epigenetics in relation to periodontitis.

Main Methods:

Literature review of studies on epigenetics and periodontitis.
Analysis of epigenetic mechanisms such as CpG island methylation, histone modification, and micro-RNA regulation.

Main Results:

Epigenetic modifications can alter gene expression relevant to periodontitis.
Gene-environment interactions, mediated by epigenetics, contribute to disease phenotype.
Chronic periodontitis has a polygenic component, with epigenetics adding another layer of complexity.

Conclusions:

Epigenetic mechanisms are implicated in the pathogenesis of periodontitis.
Further research into epigenetics can enhance understanding and treatment of periodontitis.