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Macrolide resistance in Streptococcus species.

A Ilakkiya1, Shabana Parveen2, C Naveen Kumar1

  • 1Department of Microbiology, Madha Medical College, Chennai, Tamil Nadu, India.

Journal of Pharmacy & Bioallied Sciences
|May 28, 2015
PubMed
Summary

This study investigated macrolide resistance in beta-hemolytic Streptococci, finding significant M-type resistance patterns. Antibiotic sensitivity testing is crucial for guiding treatment of Streptococcal infections.

Keywords:
Macrolide-resistantStreptococciminimum inhibitory concentration and D-test

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Area of Science:

  • Microbiology
  • Molecular Biology
  • Clinical Medicine

Background:

  • Streptococci are Gram-positive cocci forming pairs and chains.
  • Macrolide resistance in bacteria can stem from rRNA methylation, potentially plasmid or chromosomally mediated.

Purpose of the Study:

  • To determine the prevalence and degree of macrolide resistance in Streptococci isolates.
  • To identify phenotypic macrolide resistance patterns using the minimum inhibitory concentration (MIC) and D-test.

Main Methods:

  • Inclusion of patients of all age groups with respiratory and pyogenic infections from general medicine and pediatric OPDs.
  • Collection of clinical samples with detailed case histories.
  • Processing samples to detect macrolide resistance in beta-hemolytic Streptococci using MIC and D-test.

Main Results:

  • In Group A Streptococci, resistance patterns included cMLS (27.85%), iMLS (13.92%), and M-type (55.69%).
  • Group B. viridans Streptococci (GCS) showed cMLS (17.6%) and M-type (82.35%) resistance.
  • Group G Streptococci (GGS) exhibited cMLS (31.58%), iMLS (10.53%), and M-type (57.89%) resistance.

Conclusions:

  • Highlights the necessity of routine antibiotic sensitivity testing for all Streptococci isolates.
  • Emphasizes the importance of judicious antibiotic use and selecting appropriate agents for resistant strains.