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Prolidase activity in chronic plaque psoriasis patients
Hacer Altın Sürücü1, Nurten Aksoy2, Orhan Ozgöztas3
1Department of Dermatology, Harran University School of Medicine, Sanliurfa, Turkey.
Postepy Dermatologii I Alergologii
|May 28, 2015
Summary
Psoriasis patients show increased prolidase enzyme activity and elevated oxidative stress markers. These findings suggest a potential role for oxidative imbalance in the pathogenesis of this chronic skin condition.
Area of Science:
- Dermatology
- Biochemistry
- Oxidative Stress Research
Background:
- Psoriasis is a chronic, inflammatory skin disease involving T-cells and hyperproliferation.
- Collagen metabolism is altered in psoriasis due to increased prolidase activity.
Purpose of the Study:
- To measure prolidase enzyme activity in psoriasis patients.
- To investigate the relationship between prolidase activity and the oxidative system in psoriasis.
Main Methods:
- Serum samples from 40 psoriasis patients and 47 healthy controls were analyzed.
- Measurements included serum prolidase activity, total antioxidant levels, and total oxidant levels.
- Oxidative stress index was calculated for all participants.
Main Results:
- Psoriasis patients exhibited significantly higher prolidase levels, total oxidant levels, and oxidative stress index compared to controls.
- Total antioxidant levels were found to be lower in psoriasis patients.
- A positive correlation was observed between prolidase and total antioxidant/oxidant levels, but not with the oxidative stress index.
Conclusions:
- Elevated prolidase enzyme activity in psoriasis is linked to increased collagen turnover.
- Increased serum oxidants and oxidative stress indices may contribute to the development of psoriasis.
