Plasma ProBNP Is Not a Specific Marker for Transient Myocardial Ischemia.
Khawar Maqsood1, Muhammad T Shakoor2, James R Cook1
1Department of Cardiology, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA, USA.
Journal of Clinical Medicine Research
|May 28, 2015
Summary
Plasma pro-brain natriuretic peptide (proBNP) increased after cardiac procedures, limiting its use as a marker for transient myocardial ischemia during percutaneous coronary intervention (PCI). Further research is needed.
Area of Science:
- Cardiology
- Biomarkers
- Interventional Cardiology
Background:
- Elevated plasma pro-brain natriuretic peptide (proBNP) is observed in acute myocardial infarction.
- Previous research on transient myocardial ischemia's effect on plasma BNP levels yielded conflicting results.
- The current study investigated plasma proBNP in patients undergoing percutaneous coronary intervention (PCI).
Purpose of the Study:
- To evaluate plasma pro-brain natriuretic peptide (proBNP) as a marker for transient myocardial ischemia.
- To assess changes in plasma proBNP levels during and after percutaneous coronary intervention (PCI).
Main Methods:
- 49 patients with angina or abnormal stress tests undergoing cardiac catheterization were enrolled.
- Plasma proBNP levels were measured at baseline, post-procedure, and 4 hours after the procedure.
- Hotelling's T-squared test and log transformations were used for statistical analysis.
Main Results:
- Patients were divided into diagnostic catheterization (DCA) and PCI groups.
- Both groups showed a significant increase in plasma proBNP at 4 hours post-procedure (P < 0.02).
- No significant difference in the rate of proBNP increase was observed between the groups.
Conclusions:
- Plasma pro-brain natriuretic peptide (proBNP) increased in both diagnostic catheterization and PCI groups.
- This rise limits proBNP's utility in identifying transient myocardial ischemia specifically during PCI.
- The observed increase may be linked to contrast media injection, causing microcirculatory impairment and myocardial hypoxia; further investigation is warranted.
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