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A Rat Model of EcoHIV Brain Infection
Published on: January 21, 2021
Acute lower motor neuron syndrome and spinal cord gray matter hyperintensities in HIV infection
Isaac I Bogoch1, Michael R Wilson1, David A Chad1
1Divisions of Internal Medicine and Infectious Diseases (I.I.B.), University Health Network, Toronto, Ontario, Canada; Department of Medicine (I.I.B.), University of Toronto, Ontario, Canada; Department of Neurology (M.R.W.), University of California, San Francisco; Department of Neurology (D.A.C., N.V.), Massachusetts General Hospital, Boston, MA; and Harvard Medical School (D.A.C., N.V.), Boston, MA.
Objective:
To describe a novel manifestation of lower motor neuron disease in patients with well-controlled HIV infection.
Methods:
A retrospective study was performed to identify HIV-positive individuals with acute, painful lower motor neuron diseases.
Results:
Six patients were identified with HIV and lower motor neuron disease. Two patients met the inclusion criteria of well-controlled, chronic HIV infection and an acute, painful, unilateral lower motor neuron paralytic syndrome affecting the distal portion of the upper limb. These patients had segmental T2-hyperintense lesions in the central gray matter of the cervical spinal cord on MRI. One patient stabilized and the second patient improved with immunomodulatory therapy.
Conclusions:
This newly described syndrome expands the clinical spectrum of lower motor neuron diseases in HIV.
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