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Do elevated plasma S100A12 levels predict atherosclerosis in peritoneal dialysis patients?
Ozlem Yayar1, Baris Eser, Mehmet Buyukbakkal
1a Nephrology Department , Diskapi Yildirim Beyazid Research and Training Hospital , Ankara , Turkey.
Renal Failure
|May 29, 2015
Summary
Elevated S100A12 levels are linked to atherosclerosis in peritoneal dialysis (PD) patients. This protein may promote atherosclerosis, especially in aging PD patients.
Area of Science:
- Cardiovascular Research
- Nephrology
- Biochemistry
Background:
- Atherosclerotic cardiovascular disease is a leading cause of death in peritoneal dialysis (PD) patients.
- S100A12, a receptor ligand for advanced glycation end-products, is implicated in atherosclerosis development.
Purpose of the Study:
- To investigate the association between S100A12 levels and carotid atherosclerosis in PD patients.
- To determine if S100A12 is an independent risk factor for atherosclerosis in this population.
Main Methods:
- A cross-sectional study involving 56 PD patients and 20 controls.
- Plasma S100A12 levels and carotid intima-media thickness (CIMT) were measured.
- Correlation and linear regression analyses were performed.
Main Results:
- PD patients had significantly higher plasma S100A12 levels than controls.
- CIMT positively correlated with age, CRP, and S100A12 levels in PD patients.
- Age and S100A12 were identified as independent determinants of CIMT.
Conclusions:
- Elevated plasma S100A12 is closely associated with atherosclerosis in PD patients.
- S100A12 may possess significant proatherogenic potential, particularly in aging individuals on PD.
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