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Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a
Shu-Jun Fan1, Bo-Yi Yang2, Xue-Yuan Zhi3
1Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110013, China. fanfan0721ykl@163.com.
International Journal of Molecular Sciences
|May 29, 2015
Summary
This study found no significant link between MTHFR C677T and MTRR A66G gene variations and obesity in a Chinese population. Further research is needed to confirm these findings for the MTRR A66G polymorphism.
Area of Science:
- Genetics
- Obesity Research
- Population Health
Background:
- Genetic polymorphisms in methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G have been investigated for associations with overweight and obesity.
- Previous study results remain controversial and inconclusive.
Purpose of the Study:
- To investigate the association between MTHFR C677T and MTRR A66G gene polymorphisms and the risk of being overweight/obesity.
- To clarify the conflicting findings from previous research through a robust case-control study and meta-analysis.
Main Methods:
- A case-control study was conducted with 517 cases and 741 controls from a Chinese Han population.
- A comprehensive meta-analysis was performed, combining data from the current study with previous relevant studies (5431 cases and 24,896 controls).
- Statistical analyses included various genetic models (homozygous codominant, heterozygous codominant, dominant, recessive, allelic), heterogeneity assessment, sensitivity analyses, and publication bias tests.
Main Results:
- The case-control study found no significant association between the MTHFR C677T polymorphism and being overweight/obesity across all genetic models.
- The meta-analysis confirmed the case-control findings, showing no reliable association between MTHFR C677T and overweight/obesity, with minimal heterogeneity.
- Both the case-control study and meta-analysis indicated no significant link between the MTRR A66G polymorphism and overweight/obesity; however, sensitivity analyses suggested potential significance after excluding the current study's data.
Conclusions:
- The MTHFR C677T and MTRR A66G polymorphisms are unlikely to be associated with being overweight/obesity in the studied Chinese population.
- The findings suggest that these specific genetic variations may not be major risk factors for obesity.
- Further large-scale, population-based studies are recommended, particularly for the MTRR A66G polymorphism, to definitively confirm or refute these associations.
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