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Topical zinc and delayed hypersensitivity responsiveness.

D K Smith

    Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition
    |December 1, 1989
    PubMed
    Summary
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    Topical zinc may help assess zinc levels by enhancing skin test reactions. Further research is needed to confirm this method

    Area of Science:

    • Immunology
    • Nutritional Science

    Background:

    • Assessing functional zinc status is crucial for overall health.
    • Delayed-type hypersensitivity (DHR) reactions to skin test antigens can reflect immune function.

    Observation:

    • Topical zinc application appeared to enhance DHR to skin test antigens.
    • Other nutrient deficiencies, like protein deficiency, may also impact DHR.

    Findings:

    • Topical zinc may offer a simple method for evaluating functional zinc status.
    • The sensitivity and specificity of this DHR enhancement technique require further investigation.

    Implications:

    • This method could provide a straightforward way to assess zinc levels.
    • Individual variability in DHR necessitates using each patient as their own control for accurate assessment.

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