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Updated: Apr 11, 2026

Brain Imaging Investigation of the Neural Correlates of Observing Virtual Social Interactions

Brain Imaging Investigation of the Neural Correlates of Observing Virtual Social Interactions

Published on: July 6, 2011

Interoceptive predictions in the brain.

Lisa Feldman Barrett¹, W Kyle Simmons²

¹Northeastern University, Department of Psychology, Boston, Massachusetts 02115, USA; and the Massachusetts General Hospital, Department of Psychiatry and the Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA.

Nature Reviews. Neuroscience

|May 29, 2015

Summary

This summary is machine-generated.

Bodily feelings may arise from brain predictions, not just bodily sensations. This research proposes a new model where the brain predicts the body's state, potentially explaining mental and physical illnesses.

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Area of Science:

Neuroscience
Psychology
Computational Psychiatry

Background:

Traditional view: Perception follows sensation, with bodily feelings originating in the body.
Emerging evidence: Interoceptive experience may stem from limbic predictions constrained by visceral sensations.

Purpose of the Study:

Introduce the Embodied Predictive Interoception Coding (EPIC) model.
Propose a framework integrating corticocortical connections and active inference for interoception.
Explore the role of agranular visceromotor cortices in generating interoceptive predictions.

Main Methods:

Integration of anatomical models of corticocortical connections.
Application of Bayesian active inference principles.
Theoretical framework development (Opinion article).

Main Results:

The EPIC model posits that agranular visceromotor cortices generate interoceptive predictions.
Interoceptive experience is framed as a predictive process influenced by both top-down predictions and bottom-up sensations.

Conclusions:

Interoception is largely driven by the brain's predictions about the body's internal state.
Disruptions in interoceptive predictions may represent a shared vulnerability across various mental and physical health conditions.