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Updated: Apr 11, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Prevalence of auricular thrombosis before atrial flutter cardioversion: a 17-year transoesophageal echocardiographic
Alberto Cresti1, Miguel Angel García-Fernández2, Francesco De Sensi3
1Cardiological Department, Misericordia Hospital, via Senese, Grosseto 58100, Italy alcresti@gmail.com.
Insights
Atrial appendage thrombosis is common in both atrial fibrillation and flutter. Transesophageal echocardiography screening is recommended for patients with these arrhythmias lasting over 48 hours.
Area of Science:
- Cardiology
- Internal Medicine
- Diagnostic Imaging
Background:
- Atrial fibrillation (AF) has a known prevalence of left atrial appendage thrombosis (6-18%).
- Limited data exists on atrial thrombosis in persistent atrial flutter (AFL), with reported frequencies varying widely (1-21%).
Purpose of the Study:
- To determine the prevalence of atrial appendage thrombosis in patients with recent onset atrial flutter (AFL) undergoing cardioversion.
- To compare the prevalence of atrial thrombosis in AFL with that of atrial fibrillation (AF).
Main Methods:
- A retrospective analysis of 1081 patients undergoing transesophageal echocardiography (TEE)-guided cardioversion (CV) between 1999 and 2014.
- Patients included 877 with AF and 204 with AFL, with arrhythmias persisting for over 48 hours.
- Evaluation included assessment of appendage thrombosis, Doppler emptying velocities, and spontaneous echo contrast (SEC).
Main Results:
- Overall atrial thrombosis prevalence was 9.62%.
- Atrial thrombosis occurred in 6.4% of AFL patients versus 10.5% of AF patients (P=0.074).
- Left atrial appendage thrombosis was found in 5.9% of AFL patients and 9.9% of AF patients (P=0.07). Moderate to severe SEC was noted in 28% of AFL and 35% of AF patients (P=0.05).
Conclusions:
- Auricular thrombosis is a significant finding in AFL prior to cardioversion.
- TEE screening for atrial thrombosis is advisable in both AFL and AF patients presenting after more than 48 hours of arrhythmia onset.
Aims:
Prevalence of left appendage thrombosis ranges from 6 to 18% in persistent atrial fibrillation (AF). Few and low sample size studies have assessed left and right atrial thrombosis in persistent atrial flutter (AFL) and a wide variety of frequencies, from 1 to 21%, has been reported. The aim of this study was to evaluate the prevalence of atrial appendage thrombosis in a large population of patients undergoing transoesophageal echocardiography (TEE)-guided cardioversion (CV) for recent AFL onset and compare it with AF.
Methods And Results:
From 1999 to September 2014, we collected data of 1081 patients to CV: 877 affected by AF (81.1%) and 204 by AFL (18.9%). The presence of auricular thrombosis was evaluated by TEE in AF or AFL persisting for more than 48 h. The presence of appendage thrombosis, Doppler emptying velocities, and severe spontaneous echo contrast (SEC) was studied. The overall prevalence of atrial thrombosis was 9.62% (104/1081). Frequency of atrial thrombosis in AFL patients was 6.4% (13/204) vs. 10.5% among AF (92/877), P = 0.074. Comparing the two appendages, frequency of left atrial appendage thrombosis was in AFL 5.9% (12/204) vs. 9.9% (87/877) in the AF group, P = 0.07. Right atrial appendage thrombosis was present in 0.5% (1/204) in the AFL group vs. 0.8% (7/877) in the AF group, P = 0.64. Moderate to severe SEC (3+/4+) was present in 28% of AFL patients (57/204) vs. 35% of AF patients (307/877), P = 0.05.
Conclusion:
Auricular thrombosis is not an infrequent finding in AFL before CV. Our study suggests the use of TEE screening in AFL, as well as in AF, when patients arrive to clinical attention after more than 48 h from arrhythmia onset.
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