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Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

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Headache in multiple sclerosis and autoimmune disorders.

L La Mantia¹, V Prone

¹Department of Neurosciences, Niguarda Ca' Granda Hospital, Piazza Ospedale Maggiore, 3, 20162, Milan, Italy, lamantialore@gmail.com.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

|May 29, 2015

Summary

Headache is common in multiple sclerosis (MS) patients, often appearing before, during, or after diagnosis. Management strategies can improve quality of life and treatment adherence.

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Area of Science:

Neurology
Pain Medicine
Neuroimmunology

Background:

Headache is frequently observed in multiple sclerosis (MS) patients, exceeding prevalence in the general population.
Headaches can manifest at various disease stages, including pre-symptomatic, clinical onset, and throughout the disease course.

Purpose of the Study:

To review the occurrence and characteristics of headaches in multiple sclerosis.
To discuss the impact of disease-modifying therapies on headache in MS.
To explore management strategies for headache in MS patients.

Main Methods:

Literature review of studies investigating headache in multiple sclerosis.
Analysis of headache prevalence and types in MS populations.
Evaluation of the relationship between disease-modifying therapies and headache.

Main Results:

Tension-type headache and migraine without aura are the most prevalent primary headaches in MS.
Disease-modifying therapies like interferons may trigger or worsen headaches, but newer treatments show a lower risk.
Headache occurs more frequently in MS patients compared to controls.

Conclusions:

Headache is a significant symptom in multiple sclerosis, potentially linked to neuropathic pain syndromes.
Effective management of headache can enhance patient quality of life and treatment adherence.
Both pharmacological and non-pharmacological interventions should be considered for managing headaches in selected MS patients.