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Increased circulating macrophage migration inhibitory factor levels are associated with coronary artery disease

Arif Yüksel1, Ferda Bilgir2, Oktay Bilgir1

  • 1Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey.

Clinics (Sao Paulo, Brazil)
|May 29, 2015
PubMed

Insights

Macrophage migration inhibitory factor (MIF) levels were elevated in acute myocardial infarction patients, suggesting a role in atherosclerosis. E-selectin levels did not differ between patients and controls.

Area of Science:

  • Cardiology
  • Biochemistry
  • Immunology

Background:

  • Acute coronary syndrome (ACS) necessitates understanding underlying biomarkers.
  • Macrophage migration inhibitory factor (MIF) and E-selectin are implicated in inflammatory and cardiovascular diseases.

Purpose of the Study:

  • To investigate plasma levels of MIF and E-selectin in patients with ACS.
  • To compare these biomarker levels between patients with acute myocardial infarction (AMI) and non-cardiac chest pain.

Main Methods:

  • Plasma MIF and E-selectin were measured in 87 patients presenting with chest pain.
  • Patients were categorized into AMI (n=65) and control (non-cardiac chest pain, n=22) groups.
  • AMI patients were further subgrouped into ST-elevated myocardial infarction (STEMI, n=30) and non-ST-elevated myocardial infarction (NSTEMI, n=35).

Main Results:

  • Plasma MIF levels were significantly higher in both STEMI and NSTEMI subgroups compared to controls.
  • Plasma E-selectin levels showed no significant difference between AMI patients and controls.
  • No significant difference in MIF levels was observed between STEMI and NSTEMI subgroups.

Conclusions:

  • Elevated circulating MIF concentrations are associated with AMI.
  • Soluble E-selectin levels do not appear to be significantly altered in AMI.
  • MIF may play a role in the pathogenesis of atherosclerosis in ACS.
Abstract

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