Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microscopic Anatomy of Skeletal Muscles01:13

Microscopic Anatomy of Skeletal Muscles

31.2K
Skeletal muscle cells, also called muscle fibers, are distinctly elongated, multi-nucleated, slender biological units. They are packed with specialized structures designed to facilitate their primary function, which is contraction.
The muscle sarcolemma is a plasma membrane enclosing each muscle cell that conducts electrical signals called action potentials. The sarcolemma extends into the cell to form T-tubules, ensuring the neural impulses are uniformly distributed across the entire muscle...
31.2K
Skeletal Muscle Anatomy00:55

Skeletal Muscle Anatomy

95.9K
Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
95.9K
Overview of Skeletal Muscle01:15

Overview of Skeletal Muscle

17.2K
Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...
17.2K
Generation of Action Potential in Skeletal Muscles01:24

Generation of Action Potential in Skeletal Muscles

11.0K
Every cell in the body maintains a membrane potential due to an uneven distribution of positive and negative charges across its plasma membrane. The membrane potential is measured in millivolts and quantifies the difference in charge across the membrane.
Like neurons, muscle cells are also regarded as excitable due to their capacity to change in response to stimuli, primarily due to voltage-gated ion channels embedded in their plasma membranes, which get activated by alterations in the...
11.0K
The Neuromuscular Junction01:19

The Neuromuscular Junction

24.0K
The nervous system consists of complex motor neuron circuits, including upper motor neurons originating from the cerebral cortex and lower motor neurons starting in the spinal cord, coordinating both voluntary and involuntary movements. Among these, somatic motor neurons activate skeletal muscles and are classified into alpha, beta, and gamma types. Alpha neurons are vital for voluntary movement coordination, while gamma neurons adjust muscle spindle sensitivity, and the function of beta...
24.0K
Gross Anatomy of Skeletal Muscles01:12

Gross Anatomy of Skeletal Muscles

27.3K
The connective tissues play a significant role in arranging the muscle fibers into a hierarchical structure that forms a complete muscle. Consider a muscle like the bicep brachii, commonly called the bicep. This muscle comprises thousands of muscle fibers enclosed by a protective layer of connective tissue called the endomysium. The endomysium is primarily composed of reticular fibers, a type of thin collagen fiber. It allows the exchange of nutrients and waste products at the fiber level,...
27.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Altering cell size asymmetry in <i>Drosophila</i> neural stem cells creates supernumerary stem cells with limited lineage expansion potential.

bioRxiv : the preprint server for biology·2025
Same author

Heat-off responses of epidermal cells sensitize <i>Drosophila</i> larvae to noxious inputs.

bioRxiv : the preprint server for biology·2025
Same author

Inflammatory cytokine upd3 induces axon length-dependent synapse removal by glia.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

<i>Drosophila</i> epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs.

eLife·2025
Same author

Dendrite intercalation between epidermal cells tunes nociceptor sensitivity to mechanical stimuli in Drosophila larvae.

PLoS genetics·2024
Same author

A cell atlas of the larval Aedes aegypti ventral nerve cord.

Neural development·2024
Same journal

AXIN1 and AXIN2 regulate the WNT-signaling landscape to promote distinct mesoderm programs.

Developmental cell·2026
Same journal

ARID1A terminates gastric regeneration to prevent cancer.

Developmental cell·2026
Same journal

Myc sustains sex-biased organ zonation in the Drosophila intestine.

Developmental cell·2026
Same journal

Two parallel neuronal circuits involving electrical synapse and DAF-7/TGF-β signaling regulate muscle autophagy in C. elegans.

Developmental cell·2026
Same journal

Menstruation: Once unspoken but now uncovered, one cell type at a time.

Developmental cell·2026
Same journal

The ALS- and FTD-associated proteins annexin A11 and CHMP2B act sequentially in plasma membrane repair.

Developmental cell·2026
See all related articles

Related Experiment Video

Updated: Apr 11, 2026

Immunolabelling Myofiber Degeneration in Muscle Biopsies
06:37

Immunolabelling Myofiber Degeneration in Muscle Biopsies

Published on: December 5, 2019

9.7K

Muscles get dendrites into shape.

Nan Jiang1, Jay Z Parrish1

  • 1Department of Biology, University of Washington, Seattle, WA 98195, USA.

Developmental Cell
|May 29, 2015
PubMed
Summary
This summary is machine-generated.

Muscle signals guide sensory neuron development. Researchers identified a system where muscle-derived cues direct hypodermal cells, influencing sensory dendrite growth for precise neural patterning.

More Related Videos

Membrane Potentials, Synaptic Responses, Neuronal Circuitry, Neuromodulation and Muscle Histology Using the Crayfish: Student Laboratory Exercises
16:16

Membrane Potentials, Synaptic Responses, Neuronal Circuitry, Neuromodulation and Muscle Histology Using the Crayfish: Student Laboratory Exercises

Published on: January 18, 2011

60.3K
An In Vitro Adult Mouse Muscle-nerve Preparation for Studying the Firing Properties of Muscle Afferents
10:36

An In Vitro Adult Mouse Muscle-nerve Preparation for Studying the Firing Properties of Muscle Afferents

Published on: September 24, 2014

17.8K

Related Experiment Videos

Last Updated: Apr 11, 2026

Immunolabelling Myofiber Degeneration in Muscle Biopsies
06:37

Immunolabelling Myofiber Degeneration in Muscle Biopsies

Published on: December 5, 2019

9.7K
Membrane Potentials, Synaptic Responses, Neuronal Circuitry, Neuromodulation and Muscle Histology Using the Crayfish: Student Laboratory Exercises
16:16

Membrane Potentials, Synaptic Responses, Neuronal Circuitry, Neuromodulation and Muscle Histology Using the Crayfish: Student Laboratory Exercises

Published on: January 18, 2011

60.3K
An In Vitro Adult Mouse Muscle-nerve Preparation for Studying the Firing Properties of Muscle Afferents
10:36

An In Vitro Adult Mouse Muscle-nerve Preparation for Studying the Firing Properties of Muscle Afferents

Published on: September 24, 2014

17.8K

Area of Science:

  • Developmental biology
  • Neuroscience
  • Cell signaling

Background:

  • Sensory neurons and muscles interact in various biological contexts.
  • Muscle-derived signals influencing sensory dendrite patterning are not well understood.

Purpose of the Study:

  • To characterize muscle-derived signals that pattern sensory dendrites.
  • To elucidate the signaling pathway involved in directing sensory dendrite outgrowth.

Main Methods:

  • Investigated signaling mechanisms between muscle and sensory neurons.
  • Utilized genetic and cellular approaches to identify signaling molecules and pathways.

Main Results:

  • Identified a signaling system involving muscle-derived positional cues.
  • Demonstrated transduction of these cues to hypodermal cells.
  • Showed that these cues direct sensory dendrite outgrowth.

Conclusions:

  • Muscle provides positional information to pattern sensory dendrites.
  • A novel signaling pathway from muscle to hypodermis regulates neural development.