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Related Concept Videos

Blood Types02:20

Blood Types

24.7K
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
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Blood Typing01:10

Blood Typing

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Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

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HLA Typing for the Next Generation.

Neema P Mayor1, James Robinson1, Alasdair J M McWhinnie2

  • 1Anthony Nolan Research Institute, Royal Free Hospital, London, United Kingdom; UCL Cancer Institute, Royal Free Campus, London, United Kingdom.

Plos One
|May 29, 2015
PubMed
Summary
This summary is machine-generated.

Pacific Biosciences

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Area of Science:

  • Immunogenetics
  • Genomics
  • Molecular Biology

Background:

  • High-resolution Human Leukocyte Antigen (HLA) typing is crucial for histocompatibility.
  • Current high-throughput methods often yield ambiguous results due to phasing limitations.
  • Higher resolution HLA typing is frequently limited by cost and time constraints.

Purpose of the Study:

  • To evaluate the feasibility of Pacific Biosciences' Single Molecule Real-Time (SMRT) DNA sequencing for high-resolution, high-throughput HLA typing.
  • To assess the accuracy and efficiency of SMRT DNA sequencing in resolving HLA allele-level polymorphisms.

Main Methods:

  • Utilized SMRT DNA sequencing technology to analyze seven DNA samples for HLA-A, -B, and -C typing.
  • Generated long-read sequences spanning entire HLA Class I genes to enable accurate allele identification.

Main Results:

  • SMRT DNA sequencing successfully provided accurate allele calling for HLA Class I genes.
  • Identified eight novel genomic HLA class I sequences, including four new alleles, three sequence extensions, and one corrected reference sequence.
  • Demonstrated the capability of SMRT sequencing to resolve DNA sequence polymorphisms for unambiguous HLA typing.

Conclusions:

  • SMRT DNA sequencing technology is a feasible and effective method for high-resolution and high-throughput HLA typing.
  • This technology has the potential to significantly advance HLA typing, with considerable clinical impact on organ and stem cell transplantation.
  • Accurate HLA matching is critical for successful transplantation outcomes, and SMRT sequencing offers a promising solution.