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Updated: Apr 11, 2026

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Pseudomyogenic Hemangioendothelioma Mimicking Multiple Myeloma on 18F-FDG PET/CT, Followed by Spontaneous Regression
1From the *Western University, London, ON, Canada; and †Department of Diagnostic Imaging, Cross Cancer Institute, Edmonton, AB, Canada.
Abstract:
Pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma is a rare, recently described vascular neoplasm that occurs predominantly in the distal extremities of young to middle aged adult males. In this report, we describe a patient who presented with numerous lytic bone lesions which were intensely ¹⁸F-FDG avid on PET/CT and presumed to be metastatic. Pathology revealed pseudomyogenic hemangioendothelioma. Follow-up CT showed enlargement and increasing sclerosis of several lesions, believed to represent progression; however, follow-up PET/CT confirmed a spontaneous regression of the disease.
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