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An Orthotopic Murine Model of Human Prostate Cancer Metastasis
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FGF23 promotes prostate cancer progression.

Shu Feng1, Jianghua Wang1, Yiqun Zhang2

  • 1Department of Pathology and Immunology, Baylor College of Medicine and Michael E. DeBakey Dept. of Veterans Affairs Medical Center, Houston, Texas, USA.

Oncotarget
|May 29, 2015
PubMed
Summary

Fibroblast growth factor 23 (FGF23) is found in prostate cancer cells and promotes tumor growth. Reducing FGF23 levels in prostate cancer models significantly decreased cancer cell proliferation and tumor growth.

Keywords:
FGF23endocrine fibroblast growth factorsfibroblast growth factorsprostate cancersignal transduction

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Area of Science:

  • Oncology
  • Endocrinology
  • Molecular Biology

Background:

  • Prostate cancer is a leading cause of cancer death in US men.
  • Fibroblast growth factor 23 (FGF23) is crucial for phosphate homeostasis and is typically produced by osteocytes.
  • FGF23's role in prostate cancer has not been fully elucidated.

Purpose of the Study:

  • To investigate the expression and function of FGF23 in prostate cancer.
  • To determine if FGF23 acts as a growth factor in prostate cancer progression.
  • To identify genes regulated by FGF23 in prostate cancer cells.

Main Methods:

  • Assessed FGF23 expression in prostate cancer cell lines and tissues.
  • Utilized FGF23 knockdown and exogenous FGF23 treatments in vitro.
  • Evaluated tumor growth in vivo following FGF23 knockdown.
  • Analyzed gene expression changes induced by FGF2, FGF19, and FGF23 using microarrays.

Main Results:

  • FGF23 is expressed in all tested prostate cancer cell lines and elevated in prostate cancer tissues.
  • Exogenous FGF23 increased proliferation, invasion, and anchorage-independent growth in vitro.
  • FGF23 knockdown reduced these phenotypes in vitro and decreased tumor growth in vivo.
  • FGF23 alters the expression of genes associated with prostate cancer initiation and progression.

Conclusions:

  • FGF23 functions as an autocrine, paracrine, and/or endocrine growth factor in prostate cancer.
  • FGF23 promotes prostate cancer progression through various mechanisms.
  • Targeting FGF23 may offer a therapeutic strategy for prostate cancer.