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Neuropsychological markers of mild cognitive impairment: A clinic based study from urban India
Ravikesh Tripathi1, Keshav Kumar2, Rakesh Balachandar3
1Department of Psychology, Narayana Health, Mazumdar Shaw Medical Centre, Bangalore, India.
Background:
Mild cognitive impairment (MCI) is a transitional stage between normal aging and dementia. Persons with MCI are at higher risk to develop dementia. Identifying MCI from normal aging has become a priority area of research. Neuropsychological assessment could help to identify these high risk individuals.
Objective:
To examine clinical utility and diagnostic accuracy of neuropsychological measures in identifying MCI.
Materials And Methods:
This is a cross-sectional study of 42 participants (22 patients with MCI and 20 normal controls [NC]) between the age of 60 and 80 years. All participants were screened for dementia and later a detailed neuropsychological assessment was carried out.
Results:
Persons with MCI performed significantly poorer than NC on word list (immediate and delayed recall), story recall test, stick construction delayed recall, fluency and Go/No-Go test. Measures of episodic memory especially word list delayed recall had the highest discriminating power compared with measures of semantic memory and executive functioning.
Conclusion:
Word list learning with delayed recall component is a possible candidate for detecting MCI from normal aging.
